2019
Recipient factors influencing red blood cell alloimmunization
Hendrickson J. Recipient factors influencing red blood cell alloimmunization. ISBT Science Series 2019, 15: 194-200. DOI: 10.1111/voxs.12485.Peer-Reviewed Original ResearchSickle cell diseaseRBC alloantibodiesMyelodysplastic syndromeRed blood cell alloimmunizationRed blood cell alloantibodiesRBC alloantibody formationReductionist murine modelHaemolytic transfusion reactionsType of inflammationHigh prevalence ratesForms of autoimmunityDetectable alloantibodiesRBC alloimmunizationTransfusion avoidanceTransfusion burdenAlloantibody formationAntigen matchingRecipient factorsAntibody screenPatient populationHaemolytic diseaseRBC exposureRisk factorsTransfusion reactionsMurine model
2007
An Intact Spleen Is Required for Alloimmunization to Transfused Red Blood Cells Due to Intrasplenic Activation of CD4+ T Cells.
Hendrickson J, Roback J, Hillyer C, Zimring J. An Intact Spleen Is Required for Alloimmunization to Transfused Red Blood Cells Due to Intrasplenic Activation of CD4+ T Cells. Blood 2007, 110: 453. DOI: 10.1182/blood.v110.11.453.453.Peer-Reviewed Original ResearchNon-splenectomized miceRBC alloimmunizationT cellsSplenectomized miceDivision of CD4Adoptive transferRed blood cellsPrecursor frequencyHelper T-cell precursor frequencyT cell precursor frequencyHelper T cell functionHelper T cell responsesBlood cellsHuman dose equivalentRate of alloimmunizationAntigen-specific CD4T cell responsesIgG-specific ELISACell precursor frequencyT cell functionDetectable alloantibodiesPatient populationIntact spleenLymphatic preparationsMurine model