2024
How I treat challenging transfusion cases in sickle cell disease
Chou S, Hendrickson J. How I treat challenging transfusion cases in sickle cell disease. Blood 2024 PMID: 38728382, DOI: 10.1182/blood.2023023648.Peer-Reviewed Original ResearchDelayed hemolytic transfusion reactionSickle cell diseaseRed blood cellsTransfusion of red blood cellsRed blood cell alloantibodiesRed blood cell transfusionCell diseaseHemolytic transfusion reactionsManagement of complicationsAlloimmunized patientsRh alloimmunizationCurative therapyTransfusion guidelinesTransfusion recipientsClinical dilemmaFuture transfusionsTransfusionPatient populationTransfusion casesTransfusion reactionsBlood donorsRH variantsBlood cellsAlloimmunizationMedicine providers
2023
Prior immunization against an intracellular antigen enhances subsequent red blood cell alloimmunization in mice
Jajosky R, Patel S, Wu S, Patel K, Covington M, Vallecillo-Zúniga M, Ayona D, Bennett A, Luckey C, Hudson K, Hendrickson J, Eisenbarth S, Josephson C, Zerra P, Stowell S, Arthur C. Prior immunization against an intracellular antigen enhances subsequent red blood cell alloimmunization in mice. Blood 2023, 141: 2642-2653. PMID: 36638335, PMCID: PMC10356576, DOI: 10.1182/blood.2022016588.Peer-Reviewed Original ResearchConceptsCD4 T cell responsesT cell responsesIntracellular antigensB cellsImmune primingRed blood cell alloimmunizationBlood cell alloantigensRate of alloimmunizationAdditional alloantibodiesAlloimmunization rateRBC alloantigensSubsequent transfusionsSame alloantigensPrior immunizationTransfusion recipientsDonor RBCsMouse modelNumerous antigensRBC antigensAlloantigensAlloimmunizationAntigenTransfusionAlloantibodiesRBCs
2018
Influenza Infection Induces RBC Alloimmunization By a Type 1 Interferon Dependent Mechanism
Gibb D, Liu D, Liu J, Santhanakrishnan M, Eisenbarth S, Hendrickson J. Influenza Infection Induces RBC Alloimmunization By a Type 1 Interferon Dependent Mechanism. Blood 2018, 132: 743. DOI: 10.1182/blood-2018-99-110884.Peer-Reviewed Original ResearchIFNα/βInfluenza-infected miceRBC alloimmunizationWildtype miceInfluenza infectionTransfusion recipientsRed blood cell transfusionFollicular helper cell differentiationDependent mechanismCompatible blood productsFrequency of alloimmunizationVirus 3 daysBlood cell transfusionIFNα/β productionCertain autoimmune diseasesPro-inflammatory stimuliT cell proliferationInterferon-dependent mechanismRisk of alloimmunizationType 1 interferonLow baseline levelsHelper cell differentiationCell transfusionAlloimmune responseIgG responses
2017
Red blood cell alloimmunisation: induction of immunity and potential mitigation strategies
Hendrickson J. Red blood cell alloimmunisation: induction of immunity and potential mitigation strategies. ISBT Science Series 2017, 13: 105-111. DOI: 10.1111/voxs.12360.Peer-Reviewed Original ResearchAnimal modelsChronic inflammatory disease statesRBC unitsAntigen-specific toleranceT-cell markersInduction of immunityInflammatory disease statesHumoral immune responseHumoral immune responsivenessAlloantibody developmentRBC alloimmunisationDonor antigensDendritic cellsRBC alloantibodiesRBC transfusionTransfusion recipientsImmune responsivenessRBC exposureRisk factorsMurine studiesForeign antigensImmune responseCD 4Danger signalsImmune system
2006
Lack of Alloantibody Response to Red Blood Cell Antigens in Juvenile Mice Following Transfusion: Non-Immunogenic or Tolerogenic Response?.
Hendrickson J, Josephson C, Chadwick T, Zimring J. Lack of Alloantibody Response to Red Blood Cell Antigens in Juvenile Mice Following Transfusion: Non-Immunogenic or Tolerogenic Response?. Blood 2006, 108: 955. DOI: 10.1182/blood.v108.11.955.955.Peer-Reviewed Original ResearchRed blood cellsAlloantibody responsesJuvenile miceAdult miceRBC antigensPotential clinical implicationsRBC alloimmunizationClinical implicationsWeight-adjusted volumeRed blood cell antigensEffects of inflammationBlood cell antigensMonths of ageOngoing studiesViral inflammationTolerogenic responsesIgG levelsPediatric populationTransfusion recipientsImmunogenic stimulusPatient populationNeonatal humansTolerogenic stimulusMurine modelAlloimmunization
2005
Host Inflammation Increases Alloimmunization to Transfused Red Blood Cells.
Hendrickson J, Chadwick T, Roback J, Hillyer C, Zimring J. Host Inflammation Increases Alloimmunization to Transfused Red Blood Cells. Blood 2005, 106: 1887. DOI: 10.1182/blood.v106.11.1887.1887.Peer-Reviewed Original ResearchTransfusion recipientsIgG subtypesHen egg lysozymeRecipient miceHost inflammationViral infectionCo-existing infectionsDifferent IgG subtypesHemolytic transfusion reactionsActivation of macrophagesInnate immune systemUnits of RBCsBlood group antigensHumoral immunizationMimic inflammationRecipient inflammationAlloantibody responsesRed blood cellsSerious sequelaeIgG responsesAntibody titersHumoral immunityHumoral responseIgG synthesisImmunomodulatory agents