2021
Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice
Escamilla-Rivera V, Santhanakrishnan M, Liu J, Gibb DR, Forsmo JE, Foxman EF, Eisenbarth SC, Luckey CJ, Zimring JC, Hudson KE, Stowell SR, Hendrickson JE. Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice. Frontiers In Immunology 2021, 12: 704072. PMID: 34249009, PMCID: PMC8270673, DOI: 10.3389/fimmu.2021.704072.Peer-Reviewed Original ResearchConceptsImmunoprophylaxis failureRed blood cellsRBC transfusionComplement receptorsHuman KEL glycoproteinB cell activation thresholdWild-type micePresence of complementMurine red blood cellsTwo-hit modelRecipient inflammationIgG alloantibodiesInflammatory monocytesAdaptive immunityType miceB cellsRecipient complementTranslational relevanceKey cellsTransfusionMiceBlood cellsImmunoprophylaxis efficacyBaseline stateActivation threshold
2018
3 The Importance of CD4 Cells and CD40/CD40 Ligand Interactions in Humoral Immune Responses to Transfused KEL RBCs in Mice
Madrid D, Gibb D, Natarajan P, Santhanakrishnan M, Liu J, Hendrickson J. 3 The Importance of CD4 Cells and CD40/CD40 Ligand Interactions in Humoral Immune Responses to Transfused KEL RBCs in Mice. American Journal Of Clinical Pathology 2018, 149: s164-s164. DOI: 10.1093/ajcp/aqx149.372.Peer-Reviewed Original ResearchCD40/CD40 ligand interactionsCD40 ligand interactionsCD40/CD40L blockadeWild-type animalsRed blood cellsNonresponder animalsCD40L blockadeWeeks posttransfusionType animalsIgG antibodiesT cellsImmune responseMonoclonal antibodiesAbsence of CD4CD40 ligand blockadeHuman KEL glycoproteinFlow cytometric crossmatchHemolytic transfusion reactionsDurable immune responsesHumoral immune responseWild-type miceDevelopment of alloantibodiesT cell interactionsMurine red blood cellsAlloantibody responses