2022
PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development
Grinman DY, Boras-Granic K, Takyar FM, Dann P, Hens JR, Marmol C, Lee J, Choi J, Chodosh LA, Sola MEG, Wysolmerski JJ. PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development. Breast Cancer Research 2022, 24: 30. PMID: 35440032, PMCID: PMC9020078, DOI: 10.1186/s13058-022-01523-1.Peer-Reviewed Original ResearchConceptsOverexpression of PTHrPSecretory differentiationEpithelial cellsPTHrP overexpressionTumor latencyBreast cancerMammary epithelial cellsType 1 PTH/PTHrP receptorMMTV-PyMT breast cancer modelPTH/PTHrP receptorMMTV-PyMT miceMammary tumor developmentBreast cancer riskBreast cancer biologyExpression of PTHrPHormone-related proteinHuman breast cancerBreast cancer modelE74-like factor 5Normal mammary epithelial cellsBreast cancer progressionMouse mammary tumorsExpression of markersAlveolar epithelial cellsLuminal epithelial cells
2015
Chapter 13 Physiological Actions of Parathyroid Hormone (PTH) and PTH-related Protein Epidermal, Mammary, Reproductive, and Pancreatic Tissues
Wysolmerski J. Chapter 13 Physiological Actions of Parathyroid Hormone (PTH) and PTH-related Protein Epidermal, Mammary, Reproductive, and Pancreatic Tissues. 2015, 203-221. DOI: 10.1016/b978-0-12-397166-1.00013-8.Peer-Reviewed Original ResearchFunction of PTHrPParathyroid hormoneType 1 PTH/PTHrP receptorPTH/PTHrP receptorSystemic calcium metabolismHormone-related proteinNon-skeletal sitesSpecific G-proteinCalcium metabolismIntracrine factorParathyroid glandsPTHrP receptorSystemic hormonesPancreatic tissueEndocrine pancreasPTHrPPhysiological actionsMammary glandHormoneG proteinsTissueChondrocyte differentiationReceptorsGlandSkeletal development
2014
Deletion of the Nuclear Localization Sequences and C-Terminus of PTHrP Impairs Embryonic Mammary Development but also Inhibits PTHrP Production
Boras-Granic K, Dann P, VanHouten J, Karaplis A, Wysolmerski J. Deletion of the Nuclear Localization Sequences and C-Terminus of PTHrP Impairs Embryonic Mammary Development but also Inhibits PTHrP Production. PLOS ONE 2014, 9: e90418. PMID: 24785493, PMCID: PMC4006745, DOI: 10.1371/journal.pone.0090418.Peer-Reviewed Original ResearchConceptsMammary gland developmentType 1 PTH/PTHrP receptorC-terminusEmbryonic mammary gland developmentPTH/PTHrP receptorGland developmentPTHrP mRNA levelsNuclear localization signalNuclear localization sequenceHormone-related proteinEmbryonic mammary developmentMammary epithelial cellsLocalization signalNuclear functionsPTHrP productionPTHrP receptorAlternative animal modelLocalization sequencePTHR1 geneAnimal modelsEndocrine fashionMutant formsPTHrPDevelopmental defectsMesenchyme differentiation
2013
Parathyroid Hormone‐Related Protein
Wysolmerski J. Parathyroid Hormone‐Related Protein. 2013, 215-223. DOI: 10.1002/9781118453926.ch27.Peer-Reviewed Original ResearchMouse geneticsNormal biologyType I PTH/PTHrP receptorNormal developmentPTH/PTHrP receptorNormal physiologyAction of PTHHormone-related proteinGrowth factorProteinHumoral hypercalcemiaDiverse sitesParathyroid hormonePhysiologyPTHrP receptorPTHrPPTHSystemic actionMammalsHypercalcemiaGeneticsBiologyFishPTHrP.Reproduction
2012
Parathyroid Hormone-Related Protein: An Update
Wysolmerski JJ. Parathyroid Hormone-Related Protein: An Update. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: 2947-2956. PMID: 22745236, PMCID: PMC3431578, DOI: 10.1210/jc.2012-2142.BooksConceptsType 1 PTH/PTHrP receptorPTH/PTHrP receptorCauses of hypercalcemiaCommon paraneoplastic syndromeParaneoplastic syndromeHumoral hypercalcemiaParathyroid hormonePTHrP receptorBreast cancerNormal physiological functionPTHrPDisease statesTranslational researchHypercalcemiaOsteoporosisBedsidePhysiological functionsRelated genesHyperparathyroidismBasic biologyDiabetesMalignancyOsteoarthritisSyndromePTH
2001
Absence of Functional Type 1 Parathyroid Hormone (PTH)/PTH-Related Protein Receptors in Humans Is Associated with Abnormal Breast Development and Tooth Impaction1
Wysolmerski J, Cormier S, Philbrick W, Dann P, Zhang J, Roume J, Delezoide A, Silve C. Absence of Functional Type 1 Parathyroid Hormone (PTH)/PTH-Related Protein Receptors in Humans Is Associated with Abnormal Breast Development and Tooth Impaction1. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1788-1794. PMID: 11297619, DOI: 10.1210/jcem.86.4.7404.Peer-Reviewed Original ResearchConceptsParathyroid hormoneHuman breastBreast developmentType 1 PTH/PTHrP receptorBlomstrand chondrodysplasiaPTH/PTHrP receptorAbnormal breast developmentBone formationTooth developmentNormal human fetusesTooth impactionPTHrP receptorEndochondral bone formationTransgenic miceAlveolar boneHuman fetusesEndochondral bone developmentBreastSevere abnormalitiesEpithelial-mesenchymal interactionsLethal formMammary glandFetusesBone developmentTeethParathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development
Foley J, Dann P, Hong J, Cosgrove J, Dreyer B, Rimm D, Dunbar M, Philbrick W, Wysolmerski J. Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development. Development 2001, 128: 513-525. PMID: 11171335, DOI: 10.1242/dev.128.4.513.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta CateninCell DifferentiationCell LineageCytoskeletal ProteinsDNA-Binding ProteinsEpidermal CellsEpidermisEpithelial CellsFemaleGene Expression Regulation, DevelopmentalHistocytochemistryLymphoid Enhancer-Binding Factor 1Mammary Glands, AnimalMiceMice, KnockoutMice, TransgenicModels, BiologicalNipplesParathyroid Hormone-Related ProteinProteinsReceptor, Parathyroid Hormone, Type 1Receptors, Parathyroid HormoneSignal TransductionTrans-ActivatorsTranscription FactorsTransgenesConceptsPTH/PTHrP receptorCell fateHormone-related proteinMammary epithelial cell fateMammary mesenchymeCell fate decisionsEpithelial cell fatePTHrP receptorEmbryonic mammary glandMesenchymal cellsType I PTH/PTHrP receptorEmbryonic mammary developmentMammary epithelial cellsParathyroid hormone-related proteinEpithelial cellsEpithelial fateEpidermal fateFate decisionsEpithelial morphogenesisAbsence of PTHrPMesenchymal expressionVentral epidermisProper developmentSkin differentiationCombination of loss
1999
Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development
Dunbar M, Dann P, Robinson G, Hennighausen L, Zhang J, Wysolmerski J. Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development. Development 1999, 126: 3485-3493. PMID: 10409496, DOI: 10.1242/dev.126.16.3485.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedApoptosisEpithelial CellsFemaleGene Expression Regulation, DevelopmentalHeterozygoteMaleMammary Glands, AnimalMesodermMiceMice, KnockoutParathyroid Hormone-Related ProteinProteinsReceptor, Parathyroid Hormone, Type 1Receptors, AndrogenReceptors, Parathyroid HormoneSex CharacteristicsTenascinConceptsAndrogen receptorMammary mesenchymeMammary budPTH/PTHrP receptorParathyroid hormone-related proteinHormone-related proteinEpithelial budsAR expressionPTHrP expressionMale micePTHrP receptorEmbryonic mammary developmentMammary epithelial cellsEpithelial-mesenchymal signalingMammary developmentTransgenic overexpressionMammary glandBasal epidermisEpithelial cellsC expressionTenascin CVentral dermisReceptorsAndrogensPTHrP
1998
Stromal Cells Are Critical Targets in the Regulation of Mammary Ductal Morphogenesis by Parathyroid Hormone-Related Protein
Dunbar M, Young P, Zhang J, McCaughern-Carucci J, Lanske B, Orloff J, Karaplis A, Cunha G, Wysolmerski J. Stromal Cells Are Critical Targets in the Regulation of Mammary Ductal Morphogenesis by Parathyroid Hormone-Related Protein. Developmental Biology 1998, 203: 75-89. PMID: 9806774, DOI: 10.1006/dbio.1998.9029.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveCyclic AMPEmbryonic and Fetal DevelopmentEpitheliumFemaleGene Expression Regulation, DevelopmentalIn Situ HybridizationMammary Glands, AnimalMesodermMiceMice, Inbred StrainsMorphogenesisParathyroid Hormone-Related ProteinProteinsReceptors, Parathyroid HormoneRNA, MessengerStromal CellsConceptsPTH/PTHrP receptorPTHrP receptorStromal cellsMammary epithelial cell morphogenesisMammary developmentEpithelial cell morphogenesisMammary glandAmino-terminal PTHrPEpithelial cellsHormone-related proteinMammary ductal morphogenesisMammary epithelial cellsCritical targetMammary stromal cellsDuctal branching morphogenesisDevelopmental regulatory moleculeStromal cell functionMurine mammary glandCell morphogenesisMammary morphogenesisHumoral hypercalcemiaParathyroid hormoneTumor productsRegulatory moleculesMammary mesenchymeRescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development
Wysolmerski J, Philbrick W, Dunbar M, Lanske B, Kronenberg H, Karaplis A, Broadus A. Rescue of the parathyroid hormone-related protein knockout mouse demonstrates that parathyroid hormone-related protein is essential for mammary gland development. Development 1998, 125: 1285-1294. PMID: 9477327, DOI: 10.1242/dev.125.7.1285.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedGene DeletionGene Expression Regulation, DevelopmentalGene Transfer TechniquesImmunohistochemistryIn Situ HybridizationMammary Glands, AnimalMiceMice, KnockoutMorphogenesisParathyroid Hormone-Related ProteinPhenotypeProteinsReceptors, Parathyroid HormoneRNA, MessengerConceptsHormone-related proteinMammary epithelial cellsMammary gland developmentEpithelial cellsPTH/PTHrP receptor expressionPTH/PTHrP receptorParathyroid hormone-related proteinMammary glandPTH/PTHrP receptor geneAmino-terminal PTHrPMammary duct systemPTHrP-knockout miceMammary mesenchymeOverexpression of PTHrPGland developmentPTHrP receptor expressionProtein knockout miceAbsence of PTHrPSitu hybridization histochemistryAbility of PTHrPTransgenic expressionEpithelial-mesenchymal communicationNeonatal deathHumoral hypercalcemiaEarly pregnancy
1995
Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development
Wysolmerski J, McCaughern-Carucci J, Daifotis A, Broadus A, Philbrick W. Overexpression of parathyroid hormone-related protein or parathyroid hormone in transgenic mice impairs branching morphogenesis during mammary gland development. Development 1995, 121: 3539-3547. PMID: 8582268, DOI: 10.1242/dev.121.11.3539.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCell Culture TechniquesDrug ImplantsEpitheliumFemaleGene ExpressionImmunohistochemistryMammary Glands, AnimalMesodermMiceMice, TransgenicMolecular Sequence DataMorphogenesisParathyroid HormoneParathyroid Hormone-Related ProteinPolymerase Chain ReactionProteinsReceptors, Parathyroid HormoneSignal TransductionConceptsHormone-related proteinBreast developmentTransgenic miceParathyroid hormoneMyoepithelial cellsPTH/PTHrP receptorParathyroid hormone-related proteinMammary glandMammary duct systemOverexpression of PTHrPNormal breast developmentSlow-release pelletsEffects of PTHrPNormal fetal tissuesMammary gland developmentHumoral hypercalcemiaBreast hypoplasiaTumor productsPTHrP receptorNormal miceLobuloalveolar developmentTerminal ductsPTHrPFetal tissuesMice impairs