1995
CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression.
Karmann K, Hughes CC, Schechner J, Fanslow WC, Pober JS. CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 4342-4346. PMID: 7538666, PMCID: PMC41940, DOI: 10.1073/pnas.92.10.4342.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAntigens, CDAntigens, Differentiation, B-LymphocyteCD40 AntigensCell Adhesion MoleculesCells, CulturedCytokinesEndothelium, VascularGene ExpressionGranulocyte-Macrophage Colony-Stimulating FactorHumansInterferon-betaInterferon-gammaInterleukinsKineticsMiceRecombinant ProteinsSkinTumor Necrosis Factor-alphaUmbilical VeinsConceptsTumor necrosis factorAdhesion molecule-1Endothelial cellsHuman endothelial cellsNecrosis factorInterleukin-1Molecule-1T cell-mediated inflammatory reactionVascular cell adhesion molecule-1Intercellular adhesion molecule-1Cell adhesion molecule-1Cultured human umbilical vein endothelial cellsAdhesion molecule expressionLeukocyte adhesion moleculesMicrovascular endothelial cellsHuman microvascular endothelial cellsHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsFlow cytometric quantitationVein endothelial cellsCD40 antigenEndothelial CD40Interferon betaMolecule expressionInflammatory reactionPrdictive Value Of Inducible Endothelial Cell Adhesion Molecule Expression For Acte Rejection Of Human Cardiac Allografts
Briscoe DM, Yeung AC, Schoen FJ, Allred EN, Stavrakis G, Ganz P, Cotran RS, Pober JS, Schoen EL. Prdictive Value Of Inducible Endothelial Cell Adhesion Molecule Expression For Acte Rejection Of Human Cardiac Allografts. Transplantation 1995, 59: 204-211. PMID: 7530872, DOI: 10.1097/00007890-199501000-00009.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultBiopsyCD3 ComplexCell Adhesion MoleculesE-SelectinGraft RejectionHeart TransplantationHumansIntercellular Adhesion Molecule-1Longitudinal StudiesMiddle AgedMyocardial IschemiaMyocardiumPredictive Value of TestsProspective StudiesT-LymphocytesVascular Cell Adhesion Molecule-1ConceptsVascular cell adhesion molecule-1Intercellular adhesion molecule-1T-cell infiltratesHuman cardiac allograftsAdhesion molecule expressionVCAM-1 expressionAdhesion molecule-1E-selectinCardiac allograftsCell infiltrateIschemic injuryMolecule expressionEndothelial adhesion molecules intercellular adhesion molecule-1Molecule-1Adhesion molecule intercellular adhesion molecule-1Lesser extent VCAM-1Endothelial cell adhesion molecule expressionEndothelial adhesion molecule expressionAdhesion moleculesCell adhesion molecule-1Ongoing acute rejectionSuccessful antirejection therapyCardiac allograft rejectionHuman transplant recipientsImmediate posttransplant period
1993
Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture.
Petzelbauer P, Bender JR, Wilson J, Pober JS. Heterogeneity of dermal microvascular endothelial cell antigen expression and cytokine responsiveness in situ and in cell culture. The Journal Of Immunology 1993, 151: 5062-72. PMID: 7691964, DOI: 10.4049/jimmunol.151.9.5062.Peer-Reviewed Original ResearchConceptsVCAM-1 expressionDermal microvascular endothelial cellsSuperficial vascular plexusAdhesion molecule-1 expressionDeep vascular plexusMolecule-1 expressionIL-1IL-4Molecule expressionVascular bedAntigen expressionCD36 expressionEndothelial leukocyte adhesion molecule-1 expressionELAM-1Normal skinEndothelial cell antigen expressionCytokine responsivenessVascular cell adhesion molecule-1 expressionVascular plexusCapillary loopsCell adhesion molecule-1 expressionParticular vascular bedEndothelial leukocyte adhesion moleculeAdhesion molecule expressionSites of inflammationElevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1.
Pober JS, Slowik MR, De Luca LG, Ritchie AJ. Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1. The Journal Of Immunology 1993, 150: 5114-23. PMID: 7684420, DOI: 10.4049/jimmunol.150.11.5114.Peer-Reviewed Original ResearchConceptsEndothelial cellsAction of cAMPCultured human umbilical vein endothelial cellsHuman umbilical vein endothelial cellsSignal transducerUmbilical vein endothelial cellsRole of cAMPCell adhesion molecule-1Adhesion molecule-1Vein endothelial cellsCyclic monophosphatePhysiological regulatorElevated cyclic AMPVascular cell adhesion molecule-1Adhesion molecule expressionIntracellular mediatorsIsobutyl methylxanthineMolecule-1TNF inductionVCAM-1 mRNA
1992
Effects of tumor necrosis factor, lipopolysaccharide, and IL-4 on the expression of vascular cell adhesion molecule-1 in vivo. Correlation with CD3+ T cell infiltration.
Briscoe DM, Cotran RS, Pober JS. Effects of tumor necrosis factor, lipopolysaccharide, and IL-4 on the expression of vascular cell adhesion molecule-1 in vivo. Correlation with CD3+ T cell infiltration. The Journal Of Immunology 1992, 149: 2954-60. PMID: 1383333, DOI: 10.4049/jimmunol.149.9.2954.Peer-Reviewed Original ResearchConceptsT cell infiltrationEndothelial VCAM-1 expressionVCAM-1 expressionIL-4Cell infiltrationEndothelial leukocyte adhesion moleculeVCAM-1T cellsAbility of TNFT-cell-rich infiltrateImmunocytochemical stainingVascular cell adhesion molecule-1Endothelial cell adhesion molecule expressionAdhesion moleculesCell adhesion molecule-1Adhesion molecules ELAM-1Cell adhesion molecule expressionInjection of LPST cell extravasationAdhesion molecule expressionEndothelial VCAM-1Tumor necrosis factorAdhesion molecule-1Endothelial adhesion moleculesLeukocyte adhesion molecules
1991
Recruitment of neutrophils in the local endotoxin response: association with de novo endothelial expression of endothelial leukocyte adhesion molecule-1.
Munro JM, Pober JS, Cotran RS. Recruitment of neutrophils in the local endotoxin response: association with de novo endothelial expression of endothelial leukocyte adhesion molecule-1. Laboratory Investigation 1991, 64: 295-9. PMID: 1705305.Peer-Reviewed Original ResearchConceptsELAM-1 expressionEndothelial expressionAdhesion moleculesEndotoxin responseICAM-1ELAM-1Endothelial adhesion molecule expressionEndothelial leukocyte adhesion molecule-1Mononuclear cell extravasationLeukocyte adhesion molecule-1Mononuclear cell accumulationRecruitment of neutrophilsEndothelial leukocyte adhesion moleculeInjection of endotoxinICAM-1 expressionAdhesion molecule expressionPolymorphonuclear leucocyte accumulationAdhesion molecule-1Intercellular adhesion moleculeLeukocyte adhesion moleculesExtravasation of PMNsPMN accumulationEosin-stained paraffin sectionsFactor injectionsPMN infiltration