2018
Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity
Perry CJ, Muñoz-Rojas AR, Meeth KM, Kellman LN, Amezquita RA, Thakral D, Du VY, Wang JX, Damsky W, Kuhlmann AL, Sher JW, Bosenberg M, Miller-Jensen K, Kaech SM. Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity. Journal Of Experimental Medicine 2018, 215: 877-893. PMID: 29436395, PMCID: PMC5839759, DOI: 10.1084/jem.20171435.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD40 AntigensCell ProliferationImmunotherapyInflammationInterferon-gammaMacrophagesMelanoma, ExperimentalMiceMyeloid CellsNeoplasmsPhenotypeProto-Oncogene Proteins B-rafPTEN PhosphohydrolaseReceptors, Granulocyte-Macrophage Colony-Stimulating FactorRNA, MessengerSurvival AnalysisT-LymphocytesTranscription, GeneticTumor Necrosis Factor-alphaConceptsCombination therapyEffective antitumor immune responseProtective T cell responsesTumor-associated myeloid cellsM2-like stateCheckpoint inhibitor therapyAntitumor immune responseT cell responsesCSF-1R inhibitorAntitumor immunityInhibitor therapySuch patientsIL-12IL-6Cancer immunotherapyTAM subsetsUntreated tumorsT cellsImmune responseMouse modelTherapeutic targetTAM subpopulationsMyeloid cellsTumor growthCell responses
2015
Assessing Host Immune Response to Dengue Virus Infection at Single‐Cell Resolution
Sulistijo E, Miller‐Jensen K. Assessing Host Immune Response to Dengue Virus Infection at Single‐Cell Resolution. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.571.26.Peer-Reviewed Original ResearchDengue shock syndromeDENV infectionDengue hemorrhagic feverDengue virusImmune responseDHF/dengue shock syndromeDengue feverSevere dengue hemorrhagic feverLevels of cytokinesDengue virus infectionInfected cellsSignaling profilesImmune cell responsesHost immune responseHost immune systemMosquito-borne pathogenNon-infected cellsInflammatory cytokinesShock syndromeDisease progressionVirus infectionHemorrhagic feverTherapeutic targetImmune systemSuppress progression
2012
Systems biology of virus-host signaling network interactions
Xue Q, Miller-Jensen K. Systems biology of virus-host signaling network interactions. BMB Reports 2012, 45: 213-220. PMID: 22531130, DOI: 10.5483/bmbrep.2012.45.4.213.Peer-Reviewed Original ResearchConceptsVirus-host protein interactionsHost cell machineryHost protein targetsSystems biology approachVirus-mediated changesBiology approachCell machineryProtein interactionsCell variabilityViral perturbationsSystems biologyBiological contextHost cellsMolecular studiesNovel therapeutic targetIndividual pathwaysViral pathogenesisNew therapeutic strategiesTherapeutic targetComputational analysisVirus propagationHostHost responseCellsRecent advances