Hematopoietic Cell Transplant compared with Standard Care in Adolescents and Young Adults with Sickle Cell Disease
Walters M, Eapen M, Liu Y, El Rassi F, Waller E, Levine J, Strouse J, Antin J, Parikh S, Bakshi N, Dampier C, Jaroscak J, Bergmann S, Wong T, Kota V, Pace B, Lekakis L, Lulla P, Nickel R, Kasow K, Popat U, Smith W, Yu L, DiFronzo N, Geller N, Kamani N, Klings E, Hassell K, Mendizabal A, Sullivan K, Neuberg D, Krishnamurti L. Hematopoietic Cell Transplant compared with Standard Care in Adolescents and Young Adults with Sickle Cell Disease. Blood Advances 2024 PMID: 39471440, DOI: 10.1182/bloodadvances.2024013926.Peer-Reviewed Original ResearchHematopoietic cell transplantationVaso-occlusive painStandard of careSickle cell diseaseCell transplantationCell diseaseSCD-related eventsHLA-matched siblingTransplant-related mortalityPeriod of follow-upSurvival 2 yearsIntent-to-treat principleComparison of survivalDisease-modifying therapiesDisease-related mortalityUnrelated donorPrimary endpointCurative potentialTreatment armsDonor searchFollow-upCompare outcomesEligibility confirmationFunctional outcomesSecondary outcomesRisk Factors for the Development of Non-Infectious Pulmonary Complications Post-Hematopoietic Cell Transplantation in Sickle Cell Disease
Nallagatla V, Deng Y, Liang J, Krishnamurti L. Risk Factors for the Development of Non-Infectious Pulmonary Complications Post-Hematopoietic Cell Transplantation in Sickle Cell Disease. Transplantation And Cellular Therapy 2024, 30: s67. DOI: 10.1016/j.jtct.2023.12.106.Peer-Reviewed Original ResearchNon-infectious pulmonary complicationsAcute respiratory distress syndromeIdiopathic pneumonia syndromeMatched unrelated donorsPost-HCTPulmonary complicationsMechanical ventilationHLA mismatchesRisk factorsUnrelated donorCenter for International Blood and Marrow Transplant Research (CIBMTR) registryIncreased riskAssociated with pulmonary complicationsTransplant-related risk factorsPost-hematopoietic cell transplantationComplications of HCTPost-HCT complicationsHistory of ACYear of transplantationRespiratory distress syndromeTransplant-related factorsMultivariate logistic regression modelMultivariate logistic regressionDisease-related factorsPneumonia syndrome