2023
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnti-Bacterial AgentsCephalosporinsCohort StudiesDrug-Related Side Effects and Adverse ReactionsFemaleHumansMaleNeoplasmsConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
2019
Perspectives on antimicrobial use at the end of life among antibiotic stewardship programs: A survey of the Society for Healthcare Epidemiology of America Research Network
Datta R, Topal J, McManus D, Dembry LM, Quagliarello V, Juthani-Mehta M. Perspectives on antimicrobial use at the end of life among antibiotic stewardship programs: A survey of the Society for Healthcare Epidemiology of America Research Network. Infection Control And Hospital Epidemiology 2019, 40: 1074-1076. PMID: 31328703, PMCID: PMC7165360, DOI: 10.1017/ice.2019.194.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsAntimicrobial StewardshipDrug Utilization ReviewHumansPatient ComfortSurveys and QuestionnairesTerminal CareUnited StatesIncreased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures
Datta R, Zhu M, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Increased Length of Stay Associated With Antibiotic Use in Older Adults With Advanced Cancer Transitioned to Comfort Measures. American Journal Of Hospice And Palliative Medicine® 2019, 37: 27-33. PMID: 31185722, PMCID: PMC6868290, DOI: 10.1177/1049909119855617.Peer-Reviewed Original ResearchConceptsAdvanced cancerAntibiotic useComfort measuresPoisson regression modelsInfection diagnosisIntensive care unit admissionMultivariable Poisson regression modelsCare unit admissionCohort of patientsUrinary tract infectionGoal-concordant careUnit admissionEnd of lifeHospital lengthOlder patientsTract infectionsLonger LOSMedian ageRegression modelsStay AssociatedAntibiotic exposureLiquid tumorsPatientsCancerCancer typesClinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa
Nicolle LE, Gupta K, Bradley SF, Colgan R, DeMuri GP, Drekonja D, Eckert LO, Geerlings SE, Köves B, Hooton TM, Juthani-Mehta M, Knight SL, Saint S, Schaeffer AJ, Trautner B, Wullt B, Siemieniuk R. Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa. Clinical Infectious Diseases 2019, 68: 1611-1615. PMID: 31506700, DOI: 10.1093/cid/ciz021.Peer-Reviewed Original ResearchConceptsAsymptomatic bacteriuriaInfectious Diseases SocietyDiseases SocietyHealthy womenSolid organ transplantsClinical practice guidelinesSpinal cord injuryInvasive urologic proceduresNonurologic surgeryUrologic abnormalitiesClinical symptomsPregnant womenCord injuryCurrent guidelinesCommon findingHigh prevalencePractice guidelinesOrgan transplantsOlder womenUrologic proceduresAntimicrobial treatmentAdult populationAntimicrobial useAntimicrobial resistanceWomenAntibiotic-sparing agents for uncomplicated cystitis: uva-ursi and ibuprofen not ready for primetime
Datta R, Juthani-Mehta M. Antibiotic-sparing agents for uncomplicated cystitis: uva-ursi and ibuprofen not ready for primetime. Clinical Microbiology And Infection 2019, 25: 922-924. PMID: 31035018, PMCID: PMC6612576, DOI: 10.1016/j.cmi.2019.04.022.Commentaries, Editorials and LettersClinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa
Nicolle LE, Gupta K, Bradley SF, Colgan R, DeMuri GP, Drekonja D, Eckert LO, Geerlings SE, Köves B, Hooton TM, Juthani-Mehta M, Knight SL, Saint S, Schaeffer AJ, Trautner B, Wullt B, Siemieniuk R. Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of Americaa. Clinical Infectious Diseases 2019, 68: e83-e110. PMID: 30895288, DOI: 10.1093/cid/ciy1121.Peer-Reviewed Original ResearchConceptsAsymptomatic bacteriuriaInfectious Diseases SocietyDiseases SocietyHealthy womenSolid organ transplantsClinical practice guidelinesSpinal cord injuryInvasive urologic proceduresNonurologic surgeryUrologic abnormalitiesClinical symptomsPregnant womenCord injuryCurrent guidelinesCommon findingHigh prevalencePractice guidelinesOrgan transplantsOlder womenUrologic proceduresAntimicrobial treatmentAdult populationAntimicrobial useAntimicrobial resistanceWomenAntimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures
Datta R, Wang T, Zhu M, Dembry LM, Han L, Allore H, Quagliarello V, Juthani-Mehta M. Antimicrobial therapy for asymptomatic bacteriuria or candiduria in advanced cancer patients transitioning to comfort measures. Infection Control And Hospital Epidemiology 2019, 40: 470-472. PMID: 30821230, PMCID: PMC6482377, DOI: 10.1017/ice.2019.22.Peer-Reviewed Original ResearchConceptsUrinary tract infectionIncidence rate ratiosAdvanced cancer patientsAsymptomatic bacteriuriaCancer patientsAntimicrobial therapySymptomatic urinary tract infectionPotential urinary tract infectionTract infectionsInappropriate therapyAntimicrobial daysComfort measuresBacteriuriaCandiduriaCFU/mLPatientsTherapyRate ratioMLInfection
2018
Uncomplicated Cystitis in Nursing Home Residents: A Practical Guide to Diagnosis and Management
Datta R, Juthani-Mehta M. Uncomplicated Cystitis in Nursing Home Residents: A Practical Guide to Diagnosis and Management. Journal Of The American Medical Directors Association 2018, 19: 733-735. PMID: 30149841, PMCID: PMC6510384, DOI: 10.1016/j.jamda.2018.07.015.Commentaries, Editorials and LettersNitrofurantoin vs Fosfomycin: Rendering a Verdict in a Trial of Acute Uncomplicated Cystitis
Datta R, Juthani-Mehta M. Nitrofurantoin vs Fosfomycin: Rendering a Verdict in a Trial of Acute Uncomplicated Cystitis. JAMA 2018, 319: 1771-1772. PMID: 29710273, PMCID: PMC6565436, DOI: 10.1001/jama.2018.4654.Commentaries, Editorials and Letters
2017
Antimicrobial Use at the End of Life
Baghban A, Juthani-Mehta M. Antimicrobial Use at the End of Life. Infectious Disease Clinics Of North America 2017, 31: 639-647. PMID: 29079153, DOI: 10.1016/j.idc.2017.07.009.Peer-Reviewed Original Research
2016
Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial
Juthani-Mehta M, Van Ness PH, Bianco L, Rink A, Rubeck S, Ginter S, Argraves S, Charpentier P, Acampora D, Trentalange M, Quagliarello V, Peduzzi P. Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial. JAMA 2016, 316: 1879-1887. PMID: 27787564, PMCID: PMC5300771, DOI: 10.1001/jama.2016.16141.Peer-Reviewed Original ResearchConceptsUrinary tract infectionPresence of bacteriuriaSymptomatic urinary tract infectionCranberry capsulesNursing homesOlder womenTreatment groupsControl groupPlacebo-controlled efficacy trialSignificant differencesRate of deathAntibiotic-resistant organismsControl group participantsCause deathStudy surveillanceCause hospitalizationSecondary outcomesTract infectionsPrimary outcomeOverall adherenceAntimicrobial utilizationClinical trialsEfficacy trialsPyuriaUnadjusted results
2015
Antimicrobials at the End of Life: An Opportunity to Improve Palliative Care and Infection Management
Juthani-Mehta M, Malani PN, Mitchell SL. Antimicrobials at the End of Life: An Opportunity to Improve Palliative Care and Infection Management. JAMA 2015, 314: 2017-2018. PMID: 26426830, PMCID: PMC4675049, DOI: 10.1001/jama.2015.13080.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsBacterial InfectionsDecision MakingHumansRisk AssessmentTerminal CareTerminally Ill
2013
Diagnosis and Management of Urinary Tract Infection in Older Adults
Rowe TA, Juthani-Mehta M. Diagnosis and Management of Urinary Tract Infection in Older Adults. Infectious Disease Clinics Of North America 2013, 28: 75-89. PMID: 24484576, PMCID: PMC4079031, DOI: 10.1016/j.idc.2013.10.004.Peer-Reviewed Original ResearchLack of Positive Association Between Falls and Bacteriuria Plus Pyuria in Older Nursing Home Residents
Rowe T, Towle V, Van Ness P, Juthani‐Mehta M. Lack of Positive Association Between Falls and Bacteriuria Plus Pyuria in Older Nursing Home Residents. Journal Of The American Geriatrics Society 2013, 61: 653-654. PMID: 23581923, PMCID: PMC3628627, DOI: 10.1111/jgs.12177.Peer-Reviewed Original Research
2011
Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria
Das R, Towle V, Ness P, Juthani-Mehta M. Adverse Outcomes in Nursing Home Residents with Increased Episodes of Observed Bacteriuria. Infection Control And Hospital Epidemiology 2011, 32: 84-86. PMID: 21091203, PMCID: PMC3089439, DOI: 10.1086/657664.Peer-Reviewed Original Research
2009
Antimicrobial Susceptibility of Bacteria Isolated from Urine Samples Obtained from Nursing Home Residents
Das R, Perrelli E, Towle V, Van Ness PH, Juthani-Mehta M. Antimicrobial Susceptibility of Bacteria Isolated from Urine Samples Obtained from Nursing Home Residents. Infection Control And Hospital Epidemiology 2009, 30: 1116-1119. PMID: 19785518, PMCID: PMC2866029, DOI: 10.1086/647981.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAnti-Bacterial AgentsDrug Resistance, BacterialEnterobacteriaceaeEnterobacteriaceae InfectionsEscherichia coliEscherichia coli InfectionsFemaleHomes for the AgedHumansMaleMicrobial Sensitivity TestsNitrofurantoinNursing HomesTrimethoprim, Sulfamethoxazole Drug CombinationUrinary Tract InfectionsUrineConceptsUrinary tract infectionNursing home residentsTract infectionsHome residentsUrine samplesEmpiric antimicrobial therapyOral antibioticsAntibiotic therapyIndwelling catheterTrimethoprim-sulfamethoxazoleAntimicrobial therapyResistance patternsAntimicrobial susceptibilityPredominant organismTherapyInfectionResidentsCatheterNitrofurantoin