2019
Randomized placebo-controlled trial of galantamine in individuals with cocaine use disorder
DeVito EE, Carroll KM, Babuscio T, Nich C, Sofuoglu M. Randomized placebo-controlled trial of galantamine in individuals with cocaine use disorder. Journal Of Substance Use And Addiction Treatment 2019, 107: 29-37. PMID: 31757262, PMCID: PMC6918721, DOI: 10.1016/j.jsat.2019.08.009.Peer-Reviewed Original ResearchConceptsCocaine use disorderSignificant treatment group differencesUse disordersEfficacy of galantamineTreatment-seeking cocaine usersCurrent cocaine use disordersGroup differencesCocaine use outcomesSample of individualsTreatment group differencesComorbid opioid use disorderMethadone-maintained individualsMemory capacityAbstinent individualsCocaine useCognitive improvementCognitive outcomesCocaine use reductionCognitive functionUse outcomesCocaine usersGalantamine groupIndividualsDisordersInitial promiseDouble‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use
Carroll KM, DeVito EE, Yip SW, Nich C, Sofuoglu M. Double‐Blind Placebo‐Controlled Trial of Galantamine for Methadone‐Maintained Individuals With Cocaine Use Disorder: Secondary Analysis of Effects on Illicit Opioid Use. American Journal On Addictions 2019, 28: 238-245. PMID: 31165574, PMCID: PMC9078084, DOI: 10.1111/ajad.12904.Peer-Reviewed Original ResearchConceptsMethadone-maintained individualsOpioid useSecondary analysisMultiple drugsConcurrent cocaine dependenceTrial of galantaminePlacebo-controlled trialDouble-blind placeboIllicit opioid useRandomized clinical trialsCocaine use disorderGalantamine's effectFuture trialsClinical trialsUrine specimenUrine specimensUse disordersOpioidsCholinesterase inhibitorsMaintenance settingCocaine useCocaine dependencePlaceboConcurrent useGalantamine
2001
Depressive symptoms modulate the subjective and physiological response to cocaine in humans
Sofuoglu M, Brown S, Babb D, Hatsukami D. Depressive symptoms modulate the subjective and physiological response to cocaine in humans. Drug And Alcohol Dependence 2001, 63: 131-137. PMID: 11376917, DOI: 10.1016/s0376-8716(00)00199-x.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, InhalationAdultAffectArousalCocaineCocaine-Related DisordersDepressionEuphoriaFemaleHumansMaleMiddle AgedMotivationPersonality InventoryConceptsDepressive symptomsCocaine responseBeck Depression Inventory scoresHigher BDI groupLower BDI scoresDepression Inventory scoresSubclinical depressive symptomsBody weight differencesInpatient studyMajor depressionBDI scoresCocaine use behaviorBDI groupInventory scoresSymptomsCocaineCocaine usersPhysiological responsesGroup differencesEnhanced responseSubjective responsesWeight differencesScoresUse behaviorsResponseIntravenous cocaine increases plasma epinephrine and norepinephrine in humans
Sofuoglu M, Nelson D, Babb D, Hatsukami D. Intravenous cocaine increases plasma epinephrine and norepinephrine in humans. Pharmacology Biochemistry And Behavior 2001, 68: 455-459. PMID: 11325399, DOI: 10.1016/s0091-3057(01)00482-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureCocaineCocaine-Related DisordersDopamine Uptake InhibitorsEpinephrineHeart RateHumansInjections, IntravenousMaleNorepinephrineConceptsNorepinephrine concentrationsPlasma epinephrineHeart rate changesBlood pressureCocaine injectionHuman studiesPeak plasma epinephrineSympathoadrenal system activationPlacebo-controlled studyDiastolic blood pressureSystolic blood pressureDose of cocaineMale cocaine usersPlasma norepinephrineEpinephrine levelsSympathoadrenal systemCocaine administrationIntravenous injectionSystem activationIntravenous cocaineEpinephrineConsecutive daysNorepinephrineCocaineCocaine users
2000
Characteristics of research volunteers for inpatient cocaine studies Focus on selection bias
Sofuoglu M, Dudish-Poulsen S, Nicodemus K, Babb D, Hatsukami D. Characteristics of research volunteers for inpatient cocaine studies Focus on selection bias. Addictive Behaviors 2000, 25: 785-790. PMID: 11023020, DOI: 10.1016/s0306-4603(00)00064-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiasCocaine-Related DisordersFemaleHealth StatusHospitalizationHumansMalePatient SelectionResearchSurveys and QuestionnairesVolunteersCarvedilol affects the physiological and behavioral response to smoked cocaine in humans
Sofuoglu M, Brown S, Babb D, Pentel P, Hatsukami D. Carvedilol affects the physiological and behavioral response to smoked cocaine in humans. Drug And Alcohol Dependence 2000, 60: 69-76. PMID: 10821991, DOI: 10.1016/s0376-8716(00)80009-5.Peer-Reviewed Original ResearchConceptsAcute treatmentPlacebo-controlled outpatient studyPhysiological effectsEffects of carvedilolDiastolic blood pressureCocaine-induced increasesNumber of cocaineCarvedilol treatmentBlood pressureOral carvedilolOutpatient studyNoradrenergic systemAdrenergic blockersCrack cocaine usersHeart rateCarvedilolBehavioral responsesCocaineCocaine usersCocaine deliveryTreatmentSubjective responsesTreatment conditionsResponseHumansEffects of Labetalol Treatment on the Physiological and Subjective Response to Smoked Cocaine
Sofuoglu M, Brown S, Babb D, Pentel P, Hatsukami D. Effects of Labetalol Treatment on the Physiological and Subjective Response to Smoked Cocaine. Pharmacology Biochemistry And Behavior 2000, 65: 255-259. PMID: 10672977, DOI: 10.1016/s0091-3057(99)00201-4.Peer-Reviewed Original ResearchConceptsSystolic blood pressureLabetalol treatmentBlood pressureDose of labetalolEffects of labetalolSubjective responsesCocaine deliveryHeart rate increaseCocaine-induced increasesEffect of treatmentCrossover studyMedication treatmentCardiovascular responsesHeart rateAdrenergic receptorsLabetalolSmoked CocaineBehavioral effectsSubjective effectsCocaineDrug labetalolCocaine usersTreatmentDosesExperimental sessionsIndividual Differences in the Subjective Response to Smoked Cocaine in Humans
Sofuoglu M, Brown S, Dudish-Poulsen S, Hatsukami D. Individual Differences in the Subjective Response to Smoked Cocaine in Humans. The American Journal Of Drug And Alcohol Abuse 2000, 26: 591-602. PMID: 11097194, DOI: 10.1081/ada-100101897.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffectAlcohol DrinkingBlood PressureCocaineCocaine-Related DisordersCrack CocaineFemaleHeart RateHumansMaleMiddle AgedSex DistributionSmokingConceptsHeart rateBaseline Beck Depression Inventory scoresSubjective responsesBeck Depression Inventory scoresDiastolic blood pressureCocaine deliveryEffects of cocaineDepression Inventory scoresCocaine-dependent participantsBlood pressureMale sexCocaine use behaviorBody weightCocaine useSmoked CocaineAlcohol useInventory scoresCocaineCocaine usersPredictors of cardiovascular response to smoked cocaine in humans
Sofuoglu M, Nelson D, Dudish-Poulsen S, Lexau B, Pentel P, Hatsukami D. Predictors of cardiovascular response to smoked cocaine in humans. Drug And Alcohol Dependence 2000, 57: 239-245. PMID: 10661674, DOI: 10.1016/s0376-8716(99)00055-1.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, InhalationAdultArousalBlood PressureCocaine-Related DisordersCrack CocaineFemaleHeart RateHumansMaleConceptsCardiovascular responsesHeart rateHigher baseline blood pressureLong-term cocaine useCocaine useDiminished cardiovascular responseBaseline blood pressureBlood pressure changesAfrican American raceGreater cardiovascular responseCurrent cocaine useHigher body weightCardiovascular complicationsCurrent marijuana useBlood pressureMale sexCocaine administrationCurrent cocaineAmerican raceBody weightCocaineCocaine usersMarijuana usePredictorsPressure changes
1999
Sex and Menstrual Cycle Differences in the Subjective Effects From Smoked Cocaine in Humans
Sofuoglu M, Dudish-Poulsen S, Nelson D, Pentel P, Hatsukami D. Sex and Menstrual Cycle Differences in the Subjective Effects From Smoked Cocaine in Humans. Experimental And Clinical Psychopharmacology 1999, 7: 274-283. PMID: 10472516, DOI: 10.1037/1064-1297.7.3.274.Peer-Reviewed Original ResearchEffects of phenytoin on cocaine self-administration in humans1Portions of this report were presented at the 59th Annual Scientific Meeting of the College on the Problems of Drug Dependence, Nashville, June 1997.1
Sofuoglu M, Pentel P, Bliss R, Goldman A, Hatsukami D. Effects of phenytoin on cocaine self-administration in humans1Portions of this report were presented at the 59th Annual Scientific Meeting of the College on the Problems of Drug Dependence, Nashville, June 1997.1. Drug And Alcohol Dependence 1999, 53: 273-275. PMID: 10080053, DOI: 10.1016/s0376-8716(98)00140-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAnticonvulsantsCocaine-Related DisordersCrack CocaineFemaleHumansMaleMiddle AgedPatient DropoutsPhenytoinSelf AdministrationSurveys and QuestionnairesConceptsEffects of phenytoinSingle oral loading doseOral loading dosePlacebo treatment groupsEffects of cocaineHuman laboratory modelLoading doseSignificant treatment effectCocaine administrationTreatment groupsDrug dependencePhenytoinPilot studyCocaineAnnual Scientific MeetingTreatment effectsSubjective responsesScientific meetingsPlacebo