2021
Genetic associations for two biological age measures point to distinct aging phenotypes
Kuo C, Pilling LC, Liu Z, Atkins JL, Levine ME. Genetic associations for two biological age measures point to distinct aging phenotypes. Aging Cell 2021, 20: e13376. PMID: 34038024, PMCID: PMC8208797, DOI: 10.1111/acel.13376.Peer-Reviewed Original ResearchConceptsGenome-wide association scansAssociation scanEuropean descent participantsHomeostasis pathwaysPathway enrichmentAging phenotypesGenesGenetic associationCell functionStrong signalBiological age measuresPathwayUK BiobankGenetic predispositionClinical biochemistry markersImmune systemEnrichmentSNPsPhenotypeAPOE geneLipidsPredispositionDomainMarkers
2015
A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans
Levine ME, Crimmins EM. A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans. The Journals Of Gerontology Series A 2015, 71: 703-712. PMID: 26355015, PMCID: PMC4888382, DOI: 10.1093/gerona/glv141.Peer-Reviewed Original ResearchConceptsFunctional interaction networkSingle nucleotide polymorphismsStress resistanceNucleotide polymorphismsInteraction networksGenome-wide association studiesPathway analysisAssociation studiesPolygenic risk scoresNetworks AssociatedBiological networksHuman longevityUnique phenotypeHuman agingGenesPolymorphismLongevityPhenotypeInnate resilienceRisk scoreAge 52Threefold increasePathwayWeighted polygenic risk scoreResistance