2018
Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted Biopsies
Martin DT, Ghabili K, Levi A, Humphrey PA, Sprenkle PC. Prostate Cancer Genomic Classifier Relates More Strongly to Gleason Grade Group Than Prostate Imaging Reporting and Data System Score in Multiparametric Prostate Magnetic Resonance Imaging-ultrasound Fusion Targeted Biopsies. Urology 2018, 125: 64-72. PMID: 30552940, DOI: 10.1016/j.urology.2018.12.001.Peer-Reviewed Original ResearchConceptsPI-RADSv2 scoreDecipher scoreProstate Imaging ReportingDecipher testingTargeted biopsiesRadical prostatectomyData System version 2 (PI-RADS v2) scoreFavorable intermediate-risk prostate cancerIntermediate-risk prostate cancer patientsGleason Grade Group 1Imaging ReportingIntermediate-risk prostate cancerMultivariable logistic regression analysisHigh-risk diseasePI-RADS 4Grade group 1Gleason grade groupProstate cancer patientsMultiparametric magnetic resonancePI-RADS scoreVersion 2 scoreData System scoreLogistic regression analysisSignificant differencesPI-RADS category
2001
SCATTER FACTOR-HEPATOCYTE GROWTH FACTOR ELEVATION IN THE SERUM OF PATIENTS WITH PROSTATE CANCER
NAUGHTON M, PICUS J, ZHU X, CATALONA W, VOLLMER R, HUMPHREY P. SCATTER FACTOR-HEPATOCYTE GROWTH FACTOR ELEVATION IN THE SERUM OF PATIENTS WITH PROSTATE CANCER. Journal Of Urology 2001, 165: 1325-1328. DOI: 10.1097/00005392-200104000-00078.Peer-Reviewed Original ResearchMetastatic prostate cancerProstate cancerMetastatic diseaseHepatocyte growth factorPatient ageSerum levelsNegative sextant prostate biopsiesProstate-specific antigen levelHuman prostate cancer cell linesAvailable enzyme-linked immunosorbentSextant prostate biopsySpecific antigen levelsNegative sextant biopsiesProstate cancer cell linesSera of patientsMethods Serum samplesImportant serum markerLogistic regression analysisEnzyme-linked immunosorbentCancer cell linesLocalized cancerRadiographic evidenceSerum markersAntigen levelsSextant biopsySCATTER FACTOR-HEPATOCYTE GROWTH FACTOR ELEVATION IN THE SERUM OF PATIENTS WITH PROSTATE CANCER
NAUGHTON M, PICUS J, ZHU X, CATALONA W, VOLLMER R, HUMPHREY P. SCATTER FACTOR-HEPATOCYTE GROWTH FACTOR ELEVATION IN THE SERUM OF PATIENTS WITH PROSTATE CANCER. Journal Of Urology 2001, 165: 1325-1328. PMID: 11257710, DOI: 10.1016/s0022-5347(01)69893-8.Peer-Reviewed Original ResearchConceptsMetastatic prostate cancerProstate cancerMetastatic diseaseHepatocyte growth factorPatient ageSerum levelsNegative sextant prostate biopsiesProstate-specific antigen levelHuman prostate cancer cell linesAvailable enzyme-linked immunosorbentSextant prostate biopsySpecific antigen levelsNegative sextant biopsiesProstate cancer cell linesSera of patientsImportant serum markerLogistic regression analysisEnzyme-linked immunosorbentCancer cell linesLocalized cancerRadiographic evidenceSerum markersAntigen levelsSextant biopsyProstate biopsy
1993
Stratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levels
Humphrey P, Frazier H, Vollmer R, Paulson D. Stratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate‐specific antigen levels. Cancer 1993, 71: 1821-1827. PMID: 7680602, DOI: 10.1002/1097-0142(19930301)71:5<1821::aid-cncr2820710517>3.0.co;2-o.Peer-Reviewed Original ResearchConceptsPostoperative PSA levelPostoperative serum PSA levelsSerum PSA levelsRadical prostatectomy specimensIntraglandular tumor extentPSA levelsPathologic stageMargin positivityProstate-specific antigenHistologic gradeProstatectomy specimensResidual carcinomaPathologic featuresTumor extentSerum prostate-specific antigen levelPercentage carcinomaProstate-specific antigen levelExtension of carcinomaGleason histologic gradeOrgan-confined carcinomaLogistic regression analysisImportant morphologic parametersIntraglandular carcinomaAntigen levelsRadical prostatectomy
1990
Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimens
Humphrey P, Vollmer R. Intraglandular tumor extent and prognosis in prostatic carcinoma: Application of a grid method to prostatectomy specimens. Human Pathology 1990, 21: 799-804. PMID: 2387573, DOI: 10.1016/0046-8177(90)90048-a.Peer-Reviewed Original ResearchConceptsHistologic gradeTumor extentProstatectomy specimensTumor progressionPatient survivalProstatic carcinomaIntraglandular tumor extentExtent of tumorProportional hazards modelLogistic regression analysisSignificant prognosticatorPoor outcomeProstatic adenocarcinomaSurvival timeHazards modelProstatic tissueProstate glandEntire prostateProstate tissueConcurrent useTumorsCarcinomaProstateInterobserver agreement valuesProgression