Prashanth Vallabhajosyula, MD, MS
Associate Professor of Surgery (Cardiac)Cards
About
Research
Publications
2025
Direct perfusion for mesenteric ischaemia in acute type A aortic dissection: a glimpse into the mist of uncertainties
Ma W, Gao X, Ni B, Vallabhajosyula P. Direct perfusion for mesenteric ischaemia in acute type A aortic dissection: a glimpse into the mist of uncertainties. European Journal Of Cardio-Thoracic Surgery 2025, 67: ezaf044. PMID: 39951261, DOI: 10.1093/ejcts/ezaf044.Peer-Reviewed Original ResearchThe healthcare burden of isolated aortic valve insufficiency
Sultan I, Ryan M, Gunnarsson C, Heidrich N, Vallabhajosyula P. The healthcare burden of isolated aortic valve insufficiency. Scientific Reports 2025, 15: 4771. PMID: 39922868, PMCID: PMC11807181, DOI: 10.1038/s41598-025-87179-1.Peer-Reviewed Original ResearchConceptsHealthcare utilizationSAI patientsAnnual healthcare utilizationHealth care databasesYears post-diagnosisEstimate healthcare utilizationHome healthBaseline periodCare databaseMonths of continuous enrollmentCox proportional modelsPost-diagnosisAAI patientsMeasured outcomesHealthcareAI claimEstimate mortalityHealthcare burdenContinuous enrollmentExclusion criteriaUS patientsDiagnosis of aortic stenosisAortic valve insufficiencyProportional modelAnnual costEndovascular Repair vs Medical Therapy for Uncomplicated Acute Type B Dissection: Aortic Remodeling
Higaki A, Hameed I, Erez E, Hu K, Asmelash S, Chatterjee D, Shou B, Zafar M, Assi R, Vallabhajosyula P. Endovascular Repair vs Medical Therapy for Uncomplicated Acute Type B Dissection: Aortic Remodeling. Annals Of Thoracic Surgery Short Reports 2025 DOI: 10.1016/j.atssr.2025.01.012.Peer-Reviewed Original ResearchUncomplicated acute type B aortic dissectionThoracic endovascular aortic repairOptimal medical therapyMedical therapyAortic remodelingAortic levelsClinical outcomesClinical outcomes of thoracic endovascular aortic repairLumen diameterPatients treated with thoracic endovascular aortic repairOutcomes of thoracic endovascular aortic repairUncomplicated acute type B dissectionAcute type B aortic dissectionOMT patientsAcute type B dissectionType B aortic dissectionFavorable aortic remodelingOptimal initial managementInitial treatment modalityMedian follow-upType B dissectionEndovascular aortic repairB aortic dissectionFalse lumen thrombosisLeft subclavian arteryMidterm Outcomes of thoracic endovascular aortic repair versus Optimal Medical Therapy for Uncomplicated Acute Type B Dissection
Hu K, Ma W, Pupovac S, Hameed I, Fereydooni S, Li E, Larson H, Zafar M, Tonnessen B, Cardella J, Aboian E, Guzman R, Chaar C, Strosberg D, Williams M, Nassiri N, Assi R, Vallabhajosyula P. Midterm Outcomes of thoracic endovascular aortic repair versus Optimal Medical Therapy for Uncomplicated Acute Type B Dissection. JTCVS Open 2025 DOI: 10.1016/j.xjon.2024.12.013.Peer-Reviewed Original ResearchThoracic endovascular aortic repairThoracic endovascular aortic repair groupOptimal medical therapyOptimal medical therapy groupMidterm outcomes of thoracic endovascular aortic repairOutcomes of thoracic endovascular aortic repairUncomplicated acute type B aortic dissectionEndovascular aortic repairAcute kidney injuryAortic repairMidterm outcomesMedical therapyUncomplicated acute type B dissectionAcute type B aortic dissectionAcute type B dissectionAssociated with improved survivalType B aortic dissectionThirty-day ratesType B dissectionB aortic dissectionPost-operative dataMidterm follow-upIn-hospital/30-day mortalityKaplan-Meier survivalB dissectionSex-Differences in the Patterns of Cardiovascular Referral in Patients with Marfan, Ehlers-Danlos, and Loeys-Dietz Syndromes
Waldron C, Nasir A, Wang K, Chou A, Erez E, Vallabhajosyula P, Assi R. Sex-Differences in the Patterns of Cardiovascular Referral in Patients with Marfan, Ehlers-Danlos, and Loeys-Dietz Syndromes. JTCVS Open 2025 DOI: 10.1016/j.xjon.2025.01.002.Peer-Reviewed Original ResearchCardiothoracic surgeryConnective tissue diseaseFemale patientsEhlers-DanlosAortic pathologyLoeys-DietzCardiovascular medicineMale patientsTissue diseaseRetrospective review of patientsReview of patientsLoeys-Dietz syndromeDiagnosis of MFSReferral ratesSex differencesMFS patientsRetrospective reviewAortic diseaseRate of referralSurgeryPatientsMedical recordsClinical diagnosisElectronic medical recordsObjective diagnosis
2024
Successful Investigational Phage Therapy for Pan-Resistant Bacterial Mediastinitis Following Type II Hybrid Aortic Arch Replacement
Hameed I, Ahmed A, Gandhi S, Nassiri N, Steinbacher D, Vallabhajosyula P. Successful Investigational Phage Therapy for Pan-Resistant Bacterial Mediastinitis Following Type II Hybrid Aortic Arch Replacement. JACC Case Reports 2024, 29: 102816. PMID: 39691337, PMCID: PMC11646902, DOI: 10.1016/j.jaccas.2024.102816.Peer-Reviewed Original ResearchSternal wound infectionWound infectionPhage therapyStanford type B aortic dissectionThoracic endovascular aortic repairType B aortic dissectionMediastinal wound infectionsAortic arch surgeryAortic arch replacementDelayed sternal closureEndovascular aortic repairHybrid arch repairB aortic dissectionHybrid aortic arch replacementBacterial mediastinitisArch repairArch replacementArch surgeryAortic repairCardiac surgeryMediastinal drainsIntraoperative courseFlap reconstructionMorbid complicationSternal closureClinical Effectiveness of Genetic Testing Guidelines in Patients with Thoracic Aortic Aneurysms
Erez E, Acuna Higaki A, Cupo M, Phu T, Verma S, Assi R, Vallabhajosyula P. Clinical Effectiveness of Genetic Testing Guidelines in Patients with Thoracic Aortic Aneurysms. Journal Of Thoracic And Cardiovascular Surgery 2024 PMID: 39321868, DOI: 10.1016/j.jtcvs.2024.09.026.Peer-Reviewed Original ResearchFeatures of connective tissue diseaseThoracic aortic diseaseConnective tissue diseaseThoracic aortic aneurysmGenetic testing guidelinesSyndromic featuresMutation rateFamily historyVUS rateAortic aneurysmPrimary genesGenetic testingAssociated with thoracic aortic diseaseThoracic aorta diameterTesting guidelinesAorta diameterPathogen mutation rateAortic diseaseRisk stratificationSecondary genesPathogenic mutationsTissue diseaseClinical effectsVUSGenesRisk Scores (Risk Stratification)
Singh S, Vallabhajosyula P. Risk Scores (Risk Stratification). 2024, 50-55. DOI: 10.1201/9781003384779-6.Peer-Reviewed Original ResearchAge Is Just a Number: Complex Hybrid Arch Repair in a Nonagenarian
Hameed I, Ahmed A, Vallabhajosyula P. Age Is Just a Number: Complex Hybrid Arch Repair in a Nonagenarian. Canadian Journal Of Cardiology 2024, 40: 2246-2248. PMID: 39033813, DOI: 10.1016/j.cjca.2024.07.013.Peer-Reviewed Original ResearchThe role of hybrid arch repair with thoracic endovascular repair for contemporary management of complex arch and descending thoracoabdominal aortopathies
Ahmed A, Hameed I, Vallabhajosyula P. The role of hybrid arch repair with thoracic endovascular repair for contemporary management of complex arch and descending thoracoabdominal aortopathies. Journal Of Clinical Anesthesia And Intensive Care 2024, 4: 6-7. DOI: 10.46439/anesthesia.4.019.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation after Coronary Artery Bypass Surgery
HIC ID2000027269RoleSub InvestigatorPrimary Completion Date12/31/2022Recruiting ParticipantsGenderBothAge18+ yearsCorMatrix Cor TRICUSPID ECM Valve Replacement Study
HIC ID2000028726RoleSub InvestigatorPrimary Completion Date12/31/2022Recruiting ParticipantsGenderBothAge1 year - 70 years
Clinical Care
Overview
Prashanth Vallabhajosyula, MD, MS, is surgical director of the Aortic Institute, which is part of the Yale New Haven Health Heart & Vascular Center. He is a cardiothoracic surgeon who performs the entire spectrum of heart surgeries, including coronary artery bypass grafting, valve surgery, and heart transplantation. His primary focus is endovascular and open surgeries of the aorta, and hybrid surgeries that combine the two.
Dr. Vallabhajosyula is skilled in complex procedures, such as thoracic endovascular aortic repair (TEVAR), a minimally invasive procedure that uses a stent graft to reinforce an aneurysm and prevent it from bursting. He also introduced pulmonary thromboendarterectomy to Yale. The latter is a highly specialized surgical procedure that removes chronic blood clots from the arteries in the lung.
As director of the Aortic Institute, Dr. Vallabhajosyula says a large part of his work is coordinating and integrating a variety of services. “A multidisciplinary approach is important, because what we can offer patients for a particular aortic disease is rapidly evolving,” Dr. Vallabhajosyula says, explaining this that can change how different specialists can contribute to a case. “People draw arbitrary lines around what vascular surgery will do, what cardiology will do, and what a heart surgeon will do, but patients don't always understand that or come in that way. Our goal is to integrate all the services and provide a single place for patients to come if they have an aortic problem.”
Dr. Vallabhajosyula says one thing that led him to medicine was a lifelong love of science. “When I was in sixth grade, growing up in India, my mother took me to a medical university for a show they had where kids from elementary school could see human bones,” he says. “There was an anatomy lab going on, and I snuck into it and saw some cadavers. I wasn’t scared at all. I was fascinated by the human body and with seeing all these parts, and truly understanding that there is such an organic basis to everything that we do. I was hooked from the very beginning.”
He also enjoyed any experience that involved helping people, which led to his decision to be a surgeon. “Patient care is a phenomenal thing,” he says. While patients and their families are grateful for what he can do for them, he also gets a lot back, he adds. “I really try to understand patients for who they are and where they are coming from. If you approach patient care that way, you come to realize that we're all pretty similar. I think that’s made me a better person,” he says.
Clinical Specialties
Fact Sheets
Aortic Aneurysm
Learn More on Yale MedicineEndovascular Debranching Aortic Repair for Thoracoabdominal Aortic Aneurysms
Learn More on Yale MedicinePulmonary Thromboendarterectomy
Learn More on Yale MedicineReoperative Heart Surgery
Learn More on Yale Medicine
Yale Medicine News
News
News
- March 11, 2025Source: New Haven Register
How Yale doctors used a balloon in surgery to treat heart issue
- January 14, 2025
Yale Team Performs State’s First BATMAN Procedure
- June 04, 2024
Surgery Research Presented at Blavatnik Fund for Innovation at Yale
- May 02, 2024
Yale Surgeons Recognized by Connecticut Magazine's 2024 “Top Doctors” List
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Cardiac Surgery
PO Box 208062
New Haven, CT 06520-8062
United States
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