2022
Ornate, large, extremophilic (OLE) RNA forms a kink turn necessary for OapC protein recognition and RNA function
Lyon S, Harris K, Odzer N, Wilkins S, Breaker R. Ornate, large, extremophilic (OLE) RNA forms a kink turn necessary for OapC protein recognition and RNA function. Journal Of Biological Chemistry 2022, 298: 102674. PMID: 36336078, PMCID: PMC9723947, DOI: 10.1016/j.jbc.2022.102674.Peer-Reviewed Original ResearchConceptsOLE RNARNP complexesRNA-protein binding assaysPrecise biochemical functionRNA structural motifsInability of cellsNatural binding sitesRibonucleoprotein complexesRNA functionBiochemical functionsExhibit phenotypesBacterial proteinsK-turnKink turnBacillus haloduransDisruptive mutationsSame proteinBacterial speciesProtein recognitionAnaerobic bacterial speciesFunctional roleSecondary structureRNAProteinOapB
2010
Riboswitches That Sense Cyclic Di‐GMP
Lee E, Sudarsan N, Breaker R. Riboswitches That Sense Cyclic Di‐GMP. 2010, 215-229. DOI: 10.1128/9781555816667.ch15.Peer-Reviewed Original ResearchGMP riboswitchSecond messengerUntranslated regionCyclic di-GMPHigh sequence conservationAssociation of genesSecond messenger signalingSecondary structure elementsEntire regulonDifferent genetic backgroundsTranscription elongationSequence conservationRNA functionTranslation initiationLine probingDifferent environmental conditionsRiboswitchRegulatory ligandsProtein productsNew hostGenesMessenger RNAGenetic backgroundGreat diversityEnvironmental conditions
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