2024
Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)
Sheth S, Oh J, Bellone S, Siegel E, Greenman M, Mutlu L, McNamara B, Pathy S, Clark M, Azodi M, Altwerger G, Andikyan V, Huang G, Ratner E, Kim D, Iwasaki A, Levi A, Buza N, Hui P, Flaherty S, Schwartz P, Santin A. Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147). Clinical Cancer Research 2024, 30: of1-of10. PMID: 38592381, DOI: 10.1158/1078-0432.ccr-23-3639.Peer-Reviewed Original ResearchConceptsRandomized phase II trialCD4/CD8 T cellsT cellsHPV clearanceArm BNo significant differenceClinical surveillanceRate of HPV clearanceSecondary outcomesPre-neoplastic cervical lesionsCervical intraepithelial neoplasiaT cell infiltrationT cell responsesSignificant differenceCIN3 patientsIntraepithelial neoplasiaArm ACervical lesionsImiquimod groupSurveillance armVaginal suppositoriesProspective trialsArm CHPV vaccinationImiquimod
2023
Human Papillomavirus Vaccination Status and Correlates Among Mid-Adult Women: Connecticut, USA, 2016–2019
Sheth S, Johnson N, Sullivan E, Torres A, Oliveira C, Niccolai L. Human Papillomavirus Vaccination Status and Correlates Among Mid-Adult Women: Connecticut, USA, 2016–2019. Journal Of Women's Health 2023, 33: 28-32. PMID: 37943625, PMCID: PMC10794823, DOI: 10.1089/jwh.2022.0456.Peer-Reviewed Original ResearchMeSH KeywordsAdultConnecticutCross-Sectional StudiesFemaleHuman Papillomavirus VirusesHumansPapillomavirus InfectionsPapillomavirus VaccinesUnited StatesVaccinationConceptsMid-adult womenVaccination statusHPV vaccinationHPV vaccineHuman Papillomavirus Vaccination StatusHPV vaccination statusHuman papillomavirus vaccinationAge 26 yearsHealth care providersCross-sectional surveyPapillomavirus vaccinationUnvaccinated womenVaccinated womenVaccine informationCare providersVaccinationAdult womenVaccineWomenBehavioral correlatesCorrelatesStatusPotential benefitsYearsParticipantsUptake of Cervical Cancer Screening Among Female Patients Using a Mobile Medical Clinic
Degife E, Oliveira C, Znamierowski E, Meyer J, Sheth S. Uptake of Cervical Cancer Screening Among Female Patients Using a Mobile Medical Clinic. American Journal Of Preventive Medicine 2023, 65: 835-843. PMID: 37220860, PMCID: PMC10592483, DOI: 10.1016/j.amepre.2023.05.013.Peer-Reviewed Original ResearchConceptsCervical cancer screeningMobile medical clinicHealth-related social needsCervical cancerCancer screeningMedical clinicsFemale patientsCervical cancer screening uptakeCancer screening uptakeHuman papillomavirus vaccinationHigh-risk populationMultivariate logistic regressionElectronic health recordsPapillomavirus vaccinationScreening uptakePap testingRetrospective cohortPatient cohortClinic modelLower oddsPatientsUnstable housingClinicLogistic regressionCancer
2022
State Laws Permitting Adolescent Consent to Human Papillomavirus Vaccination and Rates of Immunization
Torres AR, Johnson NP, Ellingson MK, Hansen CE, Oliveira CR, Niccolai LM, Sheth SS. State Laws Permitting Adolescent Consent to Human Papillomavirus Vaccination and Rates of Immunization. JAMA Pediatrics 2022, 176: 203-205. PMID: 34779839, PMCID: PMC8593826, DOI: 10.1001/jamapediatrics.2021.4591.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent Health ServicesHumansImmunization ProgramsInformed ConsentPapillomavirus InfectionsPapillomavirus VaccinesVaccination
2021
Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States
Hosier H, Sheth SS, Oliveira CR, Perley LE, Vash-Margita A. Unindicated cervical cancer screening in adolescent females within a large healthcare system in the United States. American Journal Of Obstetrics And Gynecology 2021, 225: 649.e1-649.e9. PMID: 34256029, PMCID: PMC8633062, DOI: 10.1016/j.ajog.2021.07.005.Peer-Reviewed Original ResearchConceptsCervical cancerLarge healthcare systemYears of ageIncidence rateScreening testAdolescent femalesHealthcare systemLarge multihospital health systemCervical cancer screening resultsNew cervical cancer casesCurrent consensus recommendationsHuman papillomavirus testingHuman papillomavirus vaccinationCervical cancer casesCervical cancer screeningMultihospital health systemCancer risk reductionScreening resultsPoisson regression analysisEvidence-based strategiesGuideline nonadherencePapillomavirus vaccinationCytology testingIntraepithelial lesionsProvider factorsEffectiveness of HPV vaccine by age at vaccination and number of doses: protocol for a population-based matched case–control study
Oliveira CR, Ortiz AM, Sheth SS, Shapiro ED, Niccolai LM. Effectiveness of HPV vaccine by age at vaccination and number of doses: protocol for a population-based matched case–control study. BMJ Open 2021, 11: e043093. PMID: 33875441, PMCID: PMC8057558, DOI: 10.1136/bmjopen-2020-043093.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsCase-Control StudiesFemaleHumansPapillomavirus InfectionsPapillomavirus VaccinesUterine Cervical NeoplasmsVaccinationConceptsHigh-grade cervical lesionsPre-licensure clinical trialsHPV vaccineCase-control studyNumber of dosesClinical trialsFirst human papillomavirus (HPV) vaccineMultivariate conditional logistic regressionNormal Pap test resultsReal-world clinical settingHuman papillomavirus vaccinePap test resultsHPV types 16Time of immunisationReal-world effectivenessConditional logistic regressionInstitutional review boardDate of testingPapillomavirus vaccineCervical lesionsPotential confoundersVaccine programMedical recordsPersistent infectionType 16Association of Inadvertent 9-Valent Human Papillomavirus Vaccine in Pregnancy With Spontaneous Abortion and Adverse Birth Outcomes
Kharbanda EO, Vazquez-Benitez G, DeSilva MB, Naleway AL, Klein NP, Hechter RC, Glanz JM, Donahue JG, Jackson LA, Sheth SS, Greenberg V, Panagiotakopoulos L, Mba-Jonas A, Lipkind HS. Association of Inadvertent 9-Valent Human Papillomavirus Vaccine in Pregnancy With Spontaneous Abortion and Adverse Birth Outcomes. JAMA Network Open 2021, 4: e214340. PMID: 33818618, PMCID: PMC8022219, DOI: 10.1001/jamanetworkopen.2021.4340.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, SpontaneousAdultCohort StudiesFemaleHumansInfant, NewbornPapillomavirus InfectionsPapillomavirus VaccinesPregnancyPremature BirthStillbirthVaccinationYoung AdultConceptsVaccine exposureHuman papillomavirus vaccineAdverse birth outcomesBirth outcomesSGA birthLive birthsPapillomavirus vaccinePreterm birthSpontaneous abortionCox proportional hazards regression modelProportional hazards regression modelsVaccine Safety DatalinkMean maternal ageMedical record reviewAge 45 yearsTime of pregnancyHazards regression modelsBirth defectsMajor structural birth defectsAge 26 yearsElectronic health recordsCohort studySingleton pregnanciesFinal cohortRecord reviewInpatient Immunization With HPV Vaccine: A Qualitative Study With Postpartum Women
Avni-Singer L, Oliveira CR, Torres A, Shapiro ED, Niccolai LM, Sheth SS. Inpatient Immunization With HPV Vaccine: A Qualitative Study With Postpartum Women. Women's Health Issues 2021, 31: 384-391. PMID: 33715924, PMCID: PMC8260440, DOI: 10.1016/j.whi.2021.02.002.Peer-Reviewed Original ResearchConceptsHPV vaccinePostpartum womenPatient-centered approachHPV immunization programHuman papillomavirus vaccineRates of immunizationIterative thematic approachYoung adult femalesInpatient immunizationHospital dischargePapillomavirus vaccinePostpartum patientsMedian ageImmunization programsPatient's perspectiveProgram implementationVaccine hesitancyImmunizationVaccineWomenQualitative studyThematic approachPatientsHospitalAdult females
2020
Evaluation of an Inpatient Postpartum Human Papillomavirus Immunization Program.
Avni-Singer L, Oliveira CR, Torres A, Shapiro ED, Niccolai LM, Sheth SS. Evaluation of an Inpatient Postpartum Human Papillomavirus Immunization Program. Obstetrics And Gynecology 2020, 136: 1006-1015. PMID: 33030866, PMCID: PMC7584732, DOI: 10.1097/aog.0000000000004097.Peer-Reviewed Original ResearchConceptsHPV immunization programImmunization programsHPV vaccinePostpartum womenHuman papillomavirus immunization programmesLow-income patient populationCharacteristics of patientsRates of immunizationHospital-based obstetricsProportion of womenChi-squared testEligible visitsOutpatient doseOutpatient dosesHospital stayVaccine seriesCohort studyHospital dischargeGynecology clinicVaccine uptakePatient populationAdditional dosesSubsequent doseLogistic regressionDose
2019
Compliance with cervical cancer screening guidelines in young female patients: rates and trends of screening in New Haven County, CT
Oliveira CR, Hosier H, Pate B, Niccolai LM, Sheth SS, Vash-Margita A. Compliance with cervical cancer screening guidelines in young female patients: rates and trends of screening in New Haven County, CT. American Journal Of Obstetrics And Gynecology 2019, 221: 530-532. PMID: 31279847, PMCID: PMC6829042, DOI: 10.1016/j.ajog.2019.07.002.Peer-Reviewed Original Research
2018
Risk of Spontaneous Abortion After Inadvertent Human Papillomavirus Vaccination in Pregnancy
Kharbanda EO, Vazquez-Benitez G, Lipkind HS, Sheth SS, Zhu J, Naleway AL, Klein NP, Hechter R, Daley MF, Donahue JG, Jackson ML, Kawai AT, Sukumaran L, Nordin JD. Risk of Spontaneous Abortion After Inadvertent Human Papillomavirus Vaccination in Pregnancy. Obstetrics And Gynecology 2018, 132: 35-44. PMID: 29889760, PMCID: PMC6019196, DOI: 10.1097/aog.0000000000002694.Peer-Reviewed Original ResearchMeSH KeywordsAbortion, SpontaneousAdolescentAdultChildDatabases, FactualFemaleHuman Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18HumansMaternal ExposurePapillomaviridaePapillomavirus InfectionsPregnancyProportional Hazards ModelsRetrospective StudiesRisk FactorsStillbirthTime FactorsVaccinationYoung AdultConceptsHuman papillomavirus vaccinationSpontaneous abortionSpontaneous abortion riskPapillomavirus vaccinationCox modelAbortion riskQuadrivalent human papillomavirus vaccinationTime-dependent covariate Cox modelRetrospective observational cohortVaccine Safety DatalinkWeeks of gestationYears of agePregnancy exposureChart reviewMultiple gestationsObservational cohortWomen 12Mean agePregnancy endStandard Cox modelLive birthsPregnancyExposure windowsVaccinationHealth systemImpact of a clinical interventions bundle on uptake of HPV vaccine at an OB/GYN clinic
Deshmukh U, Oliveira CR, Griggs S, Coleman E, Avni-Singer L, Pathy S, Shapiro ED, Sheth SS. Impact of a clinical interventions bundle on uptake of HPV vaccine at an OB/GYN clinic. Vaccine 2018, 36: 3599-3605. PMID: 29759380, PMCID: PMC6314176, DOI: 10.1016/j.vaccine.2018.05.039.Peer-Reviewed Original ResearchConceptsIntervention bundleOB/GYN clinicPrevalence of womenUninsured womenVaccine uptakeAttributable reductionsMissed opportunityHPV vaccine seriesVaccine-eligible visitsVaccine-eligible womenHPV vaccine uptakeMonthly rateYoung adult womenLast study monthInterrupted time series modelHPV vaccineVaccine seriesMedical recordsHispanic womenAdult womenWhite womenStudy periodYoung adultsVaccineWomen
2017
Missed opportunities for HPV immunization among young adult women
Oliveira CR, Rock RM, Shapiro ED, Xu X, Lundsberg L, Zhang LB, Gariepy A, Illuzzi JL, Sheth SS. Missed opportunities for HPV immunization among young adult women. American Journal Of Obstetrics And Gynecology 2017, 218: 326.e1-326.e7. PMID: 29223597, PMCID: PMC5924702, DOI: 10.1016/j.ajog.2017.11.602.Peer-Reviewed Original ResearchConceptsHuman papillomavirus immunizationYoung adult womenGynecology clinicAdult womenMissed clinical opportunitiesVaccine-eligible visitsVaccine-eligible womenHuman papillomavirus vaccineMultivariable logistic regressionCross-sectional studyHospital-based obstetricsYears of ageYoung adult populationSignificant racial disparitiesUrban obstetricsPostpartum visitClinic visitsEligible womenPapillomavirus vaccinePatient characteristicsHPV immunizationHuman papillomavirusAdjusted oddsMedical recordsDifferent vaccines