Integrated genomic and functional analysis of patient-derived sarcoma cell lines validates their use for candidate treatment discovery including knockdown of a novel BCOR fusion gene.
Swierczek S, Pandya D, Billaud J, Vigil Dominguez I, Farisello S, Sieber S, Chen Y, Chuang L, Andikyan V, Martignetti J. Integrated genomic and functional analysis of patient-derived sarcoma cell lines validates their use for candidate treatment discovery including knockdown of a novel BCOR fusion gene. Journal Of Clinical Oncology 2020, 38: e23572-e23572. DOI: 10.1200/jco.2020.38.15_suppl.e23572.Peer-Reviewed Original ResearchMalignant peripheral nerve sheath tumorSomatic copy number alterationsGenomic diversityBioinformatics approachBioinformatics analysisPeritoneal nodulesFusion genePeripheral nerve sheath tumorsAggressive soft tissue sarcomaNerve sheath tumorsSoft tissue sarcomasCopy number alterationsNovel therapeutic approachesMetastatic tumor samplesRNA sequencingCell line modelsUpstream regulatorFunctional analysisDriver variantsSarcoma cell linesCell deathMPNST patientsTumor cell deathSheath tumorsWhole exome