2024
Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix
Bellone S, Jeong K, Halle M, Krakstad C, McNamara B, Greenman M, Mutlu L, Demirkiran C, Hartwich T, Yang-Hartwich Y, Zipponi M, Buza N, Hui P, Raspagliesi F, Lopez S, Paolini B, Milione M, Perrone E, Scambia G, Altwerger G, Ravaggi A, Bignotti E, Huang G, Andikyan V, Clark M, Ratner E, Azodi M, Schwartz P, Quick C, Angioli R, Terranova C, Zaidi S, Nandi S, Alexandrov L, Siegel E, Choi J, Schlessinger J, Santin A. Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2321898121. PMID: 38625939, PMCID: PMC11046577, DOI: 10.1073/pnas.2321898121.Peer-Reviewed Original ResearchConceptsWhole-exome sequencingPatient-derived-xenograftsBase excision repairCopy number lossMultiregion whole-exome sequencingCopy number gainHigh-grade neuroendocrine carcinomaCNV analysisPhylogenetic analysisEvolutionary historyNeuroendocrine cervical cancerHuman papillomavirus DNAMutator phenotypeSensitivity to afatinibGenetic landscapeRecurrent mutationsRNA sequencingGene fusionsMutational landscape analysisExcision repairGenesMutationsPan-HERConsistent with deficiencyNeuroendocrine carcinomaRandomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)
Sheth S, Oh J, Bellone S, Siegel E, Greenman M, Mutlu L, McNamara B, Pathy S, Clark M, Azodi M, Altwerger G, Andikyan V, Huang G, Ratner E, Kim D, Iwasaki A, Levi A, Buza N, Hui P, Flaherty S, Schwartz P, Santin A. Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147). Clinical Cancer Research 2024, 30: of1-of10. PMID: 38592381, DOI: 10.1158/1078-0432.ccr-23-3639.Peer-Reviewed Original ResearchConceptsRandomized phase II trialCD4/CD8 T cellsT cellsHPV clearanceArm BNo significant differenceClinical surveillanceRate of HPV clearanceSecondary outcomesPre-neoplastic cervical lesionsCervical intraepithelial neoplasiaT cell infiltrationT cell responsesSignificant differenceCIN3 patientsIntraepithelial neoplasiaArm ACervical lesionsImiquimod groupSurveillance armVaginal suppositoriesProspective trialsArm CHPV vaccinationImiquimod
2012
Extended pelvic resections for recurrent or persistent uterine and cervical malignancies: An update on out of the box surgery
Andikyan V, Khoury-Collado F, Sonoda Y, Gerst S, Alektiar K, Sandhu J, Bochner B, Barakat R, Boland P, Chi D. Extended pelvic resections for recurrent or persistent uterine and cervical malignancies: An update on out of the box surgery. Gynecologic Oncology 2012, 125: 404-408. PMID: 22285844, DOI: 10.1016/j.ygyno.2012.01.031.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedFemaleHumansMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPelvic ExenterationSurvival RateTreatment OutcomeUterine Cervical NeoplasmsUterine NeoplasmsConceptsExtended pelvic resectionR0 resectionPostoperative complicationsOverall survivalCervical malignancyPelvic resectionPositive pathologic marginsUterus/cervixMajor postoperative complicationsOutcomes of patientsComplete gross resectionKaplan-Meier methodMedian tumor diameterDays post surgeryEn bloc resectionMajor vascular structuresPrimary tumor siteUterus/Perioperative mortalityCommon morbidityGross resectionMedian agePeripheral neuropathyPost surgeryPelvic abscess
2003
Fluoreszenzdiagnostik mit 5-ALA-Thermogel bei zervikaler intraepithelialer Neoplasie
Andikyan V, Kronschnabl M, Hillemanns M, Wang X, Stepp H, Hillemanns P. Fluoreszenzdiagnostik mit 5-ALA-Thermogel bei zervikaler intraepithelialer Neoplasie. Gynäkologische Rundschau 2003, 44: 31-37. PMID: 14673226, DOI: 10.1159/000074315.Peer-Reviewed Original ResearchConceptsCervical intraepithelial neoplasiaNormal adjacent epitheliumCIN 3Female patientsIntraepithelial neoplasiaCIN 1CIN lesionsCervix uteriDysplastic epitheliumHistological examinationAdjacent epitheliumPorphyrin fluorescence intensityNormal ratioTumor selectivityDrug applicationBody temperatureLesionsPhotodynamic therapyGel formulationTwofold increaseEpitheliumEpithelial tissuesMaximal intensityFormulation 4