2014
Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin Replication
Jacob Y, Bergamin E, Donoghue MT, Mongeon V, LeBlanc C, Voigt P, Underwood CJ, Brunzelle JS, Michaels SD, Reinberg D, Couture JF, Martienssen RA. Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin Replication. Science 2014, 343: 1249-1253. PMID: 24626927, PMCID: PMC4049228, DOI: 10.1126/science.1248357.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceArabidopsisArabidopsis ProteinsCatalytic DomainConserved SequenceCrystallography, X-RayDNA ReplicationEpigenesis, GeneticGene Expression Regulation, PlantHeterochromatinHistonesMethylationMethyltransferasesMitosisMolecular Sequence DataProtein Processing, Post-TranslationalThreonineConceptsHistone H3 variantWidespread regulatory functionsHistone-modifying enzymesARABIDOPSIS TRITHORAXMitotic inheritanceH3 variantHistone variantsHeterochromatin replicationSET domainDNA replicationPosttranslational modificationsCatalytic domainRegulatory functionsPosition 31Protein 5ATXR5H3.3Selective methylationReplicationATXR6TrithoraxH3K27me1ParalogsHeterochromatizationH3.1
2010
Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases
Jacob Y, Stroud H, LeBlanc C, Feng S, Zhuo L, Caro E, Hassel C, Gutierrez C, Michaels SD, Jacobsen SE. Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases. Nature 2010, 466: 987-991. PMID: 20631708, PMCID: PMC2964344, DOI: 10.1038/nature09290.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsArabidopsisArabidopsis ProteinsCatalytic DomainDNA MethylationDNA ReplicationDNA Transposable ElementsDNA, PlantGene Expression Regulation, PlantGene SilencingGenome, PlantHeterochromatinHistone-Lysine N-MethyltransferaseHistonesLysineMethylationMethyltransferasesMutant ProteinsMutationReplication Origin
2009
ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing
Jacob Y, Feng S, LeBlanc CA, Bernatavichute YV, Stroud H, Cokus S, Johnson LM, Pellegrini M, Jacobsen SE, Michaels SD. ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. Nature Structural & Molecular Biology 2009, 16: 763-768. PMID: 19503079, PMCID: PMC2754316, DOI: 10.1038/nsmb.1611.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArabidopsisArabidopsis ProteinsGene Expression Regulation, PlantGene SilencingHeterochromatinHistonesLysineMethyltransferasesMutation