2021
H3.1K27me1 maintains transcriptional silencing and genome stability by preventing GCN5-mediated histone acetylation
Dong J, LeBlanc C, Poulet A, Mermaz B, Villarino G, Webb KM, Joly V, Mendez J, Voigt P, Jacob Y. H3.1K27me1 maintains transcriptional silencing and genome stability by preventing GCN5-mediated histone acetylation. The Plant Cell 2021, 33: 961-979. PMID: 33793815, PMCID: PMC8226292, DOI: 10.1093/plcell/koaa027.Peer-Reviewed Original ResearchConceptsGenome stabilityGenomic instabilityHistone acetylationSAGA-like complexesMultiple lysine residuesArabidopsis GCN5ARABIDOPSIS TRITHORAXArabidopsis thalianaTranscriptional silencingHeterochromatin defectsDouble mutantDNA replicationEpigenetic mechanismsGCN5Molecular roleEssential functionsDiverse rolesMolecular mechanismsLysine residuesProtein 5AcetylationMutantsPlantsADA2bATXR6
2010
Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases
Jacob Y, Stroud H, LeBlanc C, Feng S, Zhuo L, Caro E, Hassel C, Gutierrez C, Michaels SD, Jacobsen SE. Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases. Nature 2010, 466: 987-991. PMID: 20631708, PMCID: PMC2964344, DOI: 10.1038/nature09290.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid MotifsArabidopsisArabidopsis ProteinsCatalytic DomainDNA MethylationDNA ReplicationDNA Transposable ElementsDNA, PlantGene Expression Regulation, PlantGene SilencingGenome, PlantHeterochromatinHistone-Lysine N-MethyltransferaseHistonesLysineMethylationMethyltransferasesMutant ProteinsMutationReplication Origin
2009
ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing
Jacob Y, Feng S, LeBlanc CA, Bernatavichute YV, Stroud H, Cokus S, Johnson LM, Pellegrini M, Jacobsen SE, Michaels SD. ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. Nature Structural & Molecular Biology 2009, 16: 763-768. PMID: 19503079, PMCID: PMC2754316, DOI: 10.1038/nsmb.1611.Peer-Reviewed Original Research