Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution
Gu H, Bock C, Mikkelsen TS, Jäger N, Smith ZD, Tomazou E, Gnirke A, Lander ES, Meissner A. Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution. Nature Methods 2010, 7: 133-136. PMID: 20062050, PMCID: PMC2860480, DOI: 10.1038/nmeth.1414.Peer-Reviewed Original ResearchConceptsReduced-representation bisulfite sequencingDNA methylation mappingGenome-scale mappingSingle-nucleotide resolutionMethylation mappingBisulfite sequencingDNA methylationDNA amountMethylationSequencingDNAMappingClinical samples