2019
Differential regulation of OCT4 targets facilitates reacquisition of pluripotency
Thakurela S, Sindhu C, Yurkovsky E, Riemenschneider C, Smith ZD, Nachman I, Meissner A. Differential regulation of OCT4 targets facilitates reacquisition of pluripotency. Nature Communications 2019, 10: 4444. PMID: 31570708, PMCID: PMC6768871, DOI: 10.1038/s41467-019-11741-5.Peer-Reviewed Original ResearchConceptsEctopic transcription factorsReacquisition of pluripotencySomatic cell reprogrammingCis-regulatory elementsTranscription factor expressionExact molecular mechanismsOCT4 targetsPluripotent stem cellsPluripotency inductionCell reprogrammingTranscription factorsSomatic cellsMolecular mechanismsDifferential regulationPluripotencyStem cellsVivo differentiationPrimary targetCellsFactor expressionFinal stepExperimental systemReprogrammingTargetDifferentiation
2013
Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition
Zhang RR, Cui QY, Murai K, Lim YC, Smith ZD, Jin S, Ye P, Rosa L, Lee YK, Wu HP, Liu W, Xu ZM, Yang L, Ding YQ, Tang F, Meissner A, Ding C, Shi Y, Xu GL. Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition. Cell Stem Cell 2013, 13: 237-245. PMID: 23770080, PMCID: PMC4474382, DOI: 10.1016/j.stem.2013.05.006.Peer-Reviewed Original ResearchConceptsNeural progenitor cell proliferationProgenitor cell proliferationCohort of genesEmbryonic stem cellsCell proliferationNeural progenitor cellsAdult neural progenitor cellsTET dioxygenasesEpigenetic regulationAdult mouse brainBiological functionsHippocampal neurogenesisProgenitor proliferationTET1DNA hydroxylationStem cellsProgenitor cellsAdult hippocampal neurogenesisAdult brainProliferationMouse brainNeurogenesisImportant roleCellsDioxygenases