2024
A phase II trial of UGT1A1 genotype-guided FOLFIRI plus bevacizumab as first-line therapy for advanced, unresectable colorectal cancer
Sanoff H, Deal A, Patel J, Sorah J, Gaddy J, O’Neil B, Turk A, Irvin W, Boles J, Lee M, McRee A, Wardell A, Weck K, Basch E, Wood W, Innocenti F. A phase II trial of UGT1A1 genotype-guided FOLFIRI plus bevacizumab as first-line therapy for advanced, unresectable colorectal cancer. The Oncologist 2024, oyae122. PMID: 38837045, DOI: 10.1093/oncolo/oyae122.Peer-Reviewed Original ResearchProgression-free survivalMetastatic colorectal cancerOverall survivalIrinotecan doseColorectal cancerMedian progression-free survivalMetastatic colorectal cancer patientsEstimates of overall survivalFirst-line settingUnresectable colorectal cancerRates of neutropeniaFirst-line therapyPhase II trialPatient-reported adverse eventsRate of diarrheaG3/4 toxicitiesUGT1A1 genotypeIrinotecan metabolismFirst-linePrimary endpointSecondary endpointsAdverse eventsFOLFIRIHistorical controlsNon-genotype
2023
Abstract C129: Impact of COVID-19 on colorectal cancer screening disparities: Results from a large commercially insured population in the United States
Siddique A, Wang R, Gaddy J, Gross C, Ma X. Abstract C129: Impact of COVID-19 on colorectal cancer screening disparities: Results from a large commercially insured population in the United States. Cancer Epidemiology Biomarkers & Prevention 2023, 32: c129-c129. DOI: 10.1158/1538-7755.disp23-c129.Peer-Reviewed Original ResearchBlue Cross Blue ShieldColorectal cancer screeningColorectal cancer screening disparitiesLow socioeconomic statusCancer screening disparitiesScreening ratesHigher socioeconomic statusSocioeconomic statusScreening disparitiesCommercially insured populationColorectal cancerColorectal cancer screening ratesImpact of COVID-19Burden of colorectal cancerColorectal cancer incidenceCancer health disparitiesCRC-related mortalityNeighborhood socioeconomic statusSocioeconomic status quintileSocial deprivation indexSocioeconomic status areasNon-Hispanic blacksNon-urgent careSocially deprived areasEthnic minoritized populations