2024
Proteolysis and Contractility Regulate Tissue Opening and Wound Healing by Lung Fibroblasts in 3D Microenvironments
Xiao H, Sylla K, Gong X, Wilkowski B, Rossello‐Martinez A, Jordan S, Mintah E, Zheng A, Sun H, Herzog E, Mak M. Proteolysis and Contractility Regulate Tissue Opening and Wound Healing by Lung Fibroblasts in 3D Microenvironments. Advanced Healthcare Materials 2024, e2400941. PMID: 38967294, DOI: 10.1002/adhm.202400941.Peer-Reviewed Original ResearchBiophysical and biochemical aspects of immune cell–tumor microenvironment interactions
Benmelech S, Le T, McKay M, Nam J, Subramaniam K, Tellez D, Vlasak G, Mak M. Biophysical and biochemical aspects of immune cell–tumor microenvironment interactions. APL Bioengineering 2024, 8: 021502. PMID: 38572312, PMCID: PMC10990568, DOI: 10.1063/5.0195244.Peer-Reviewed Original ResearchTumor microenvironmentImprove CAR T cell therapyCAR-T cell therapyCD4+ T cellsCancer cellsAdaptive immune systemDistribution of cancer cellsCD8+T cellsImmunosuppressive responsePro-tumorImmune cellsMicroenvironment interactionsCell therapyExtracellular matrixCancer progressionImmune systemTumorCells-thatSpatial distribution of cancer cellsCancerCellsCD8CD4TherapyAdaptation to mechanical stresses drives an apoptosis-resistant and invasive phenotype in liver cells
Gong X, Ogino N, de Fátima Leite M, Chen Z, Nguyen R, Liu R, Kruglov E, Flores K, Cabral A, de M. Mendes G, Ehrlich B, Mak M. Adaptation to mechanical stresses drives an apoptosis-resistant and invasive phenotype in liver cells. Biophysical Journal 2024, 123: 177a. DOI: 10.1016/j.bpj.2023.11.1163.Peer-Reviewed Original Research
2023
Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility
Böhringer D, Bauer A, Moravec I, Bischof L, Kah D, Mark C, Grundy T, Görlach E, O'Neill G, Budday S, Strissel P, Strick R, Malandrino A, Gerum R, Mak M, Rausch M, Fabry B. Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility. Matrix Biology 2023, 124: 39-48. PMID: 37967726, PMCID: PMC10872942, DOI: 10.1016/j.matbio.2023.11.004.Peer-Reviewed Original ResearchConceptsCellular traction forcesTraction forceHepatic stellate cellsMatrix remodelingGlioblastoma cell linesFiber orientationCell contractilityDrug screening assaysLocal fiber orientationCell forcesRho-kinaseFiber alignmentStellate cellsCell linesScreening assayFiber networkCellsPython packageMechanical propertiesForce reconstructionBiopolymer matrixRemodelingInduced deformationQualitative proxyCollagen network