Featured Publications
Strategies of neutrophil diversification
Palomino-Segura M, Sicilia J, Ballesteros I, Hidalgo A. Strategies of neutrophil diversification. Nature Immunology 2023, 24: 575-584. PMID: 36959290, PMCID: PMC10139675, DOI: 10.1038/s41590-023-01452-x.Peer-Reviewed Original ResearchA Network of Macrophages Supports Mitochondrial Homeostasis in the Heart
Nicolás-Ávila JA, Lechuga-Vieco AV, Esteban-Martínez L, Sánchez-Díaz M, Díaz-García E, Santiago DJ, Rubio-Ponce A, Li JL, Balachander A, Quintana JA, Martínez-de-Mena R, Castejón-Vega B, Pun-García A, Través PG, Bonzón-Kulichenko E, García-Marqués F, Cussó L, A-González N, González-Guerra A, Roche-Molina M, Martin-Salamanca S, Crainiciuc G, Guzmán G, Larrazabal J, Herrero-Galán E, Alegre-Cebollada J, Lemke G, Rothlin CV, Jimenez-Borreguero LJ, Reyes G, Castrillo A, Desco M, Muñoz-Cánoves P, Ibáñez B, Torres M, Ng LG, Priori SG, Bueno H, Vázquez J, Cordero MD, Bernal JA, Enríquez JA, Hidalgo A. A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart. Cell 2020, 183: 94-109.e23. PMID: 32937105, DOI: 10.1016/j.cell.2020.08.031.Peer-Reviewed Original ResearchConceptsPhagocytic receptor MertkNetwork of macrophagesVentricular dysfunctionCardiac stressCardiac macrophagesDefective eliminationMetabolic alterationsOrgan functionImpaired autophagyHealthy myocardiumMyocardial tissueMurine heartMacrophagesMetabolic demandsCardiomyocytesMetabolic stabilityHeartAutophagy machineryMitochondrial homeostasisDysfunctional mitochondriaHomeostasisMembranous particlesDysfunctionInflammasomeMyocardium
2023
The circadian neutrophil, inside-out
Ovadia S, Özcan A, Hidalgo A. The circadian neutrophil, inside-out. Journal Of Leukocyte Biology 2023, 113: 555-566. PMID: 36999376, PMCID: PMC10583762, DOI: 10.1093/jleuko/qiad038.Peer-Reviewed Original Research
2013
Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance
Casanova-Acebes M, Pitaval C, Weiss LA, Nombela-Arrieta C, Chèvre R, A-González N, Kunisaki Y, Zhang D, van Rooijen N, Silberstein LE, Weber C, Nagasawa T, Frenette PS, Castrillo A, Hidalgo A. Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance. Cell 2013, 153: 1025-1035. PMID: 23706740, PMCID: PMC4128329, DOI: 10.1016/j.cell.2013.04.040.Peer-Reviewed Original ResearchConceptsBone marrowFunction of neutrophilsNeutrophil clearanceHomeostatic clearanceHematopoietic nicheNeutrophil eliminationHomeostatic signalsAged neutrophilsNeutrophilsRhythmic modulationMarrowCircadian eventsNuclear receptorsHematopoietic progenitorsClearanceInflammationLeukocytesMiceMacrophagesCirculationReceptors
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