2025
A human gut bacterium antagonizes neighboring bacteria by altering their protein-folding ability
Lim B, Xu J, Wierzbicki I, Gonzalez C, Chen Z, Gonzalez D, Gao X, Goodman A. A human gut bacterium antagonizes neighboring bacteria by altering their protein-folding ability. Cell Host & Microbe 2025, 33: 200-217.e24. PMID: 39909037, DOI: 10.1016/j.chom.2025.01.008.Peer-Reviewed Original ResearchConceptsHuman gut microbesChaperone complexGut microbesCommunity dynamicsHuman gut bacteriumProtein folding abilityProtein folding capacityHuman gut microbiomeMicrobial community dynamicsGut metagenomesNeighboring bacteriaExpression strainGut bacteriumMammalian gutFitness advantageGut microbiomeAllelic variationGenetic characterizationPathogen-induced inflammationSubstrate aggregationAntagonistic interactionsMicrobesRecipient cellsGutNeighboring cells
2016
Human symbionts inject and neutralize antibacterial toxins to persist in the gut
Wexler AG, Bao Y, Whitney JC, Bobay LM, Xavier JB, Schofield WB, Barry NA, Russell AB, Tran BQ, Goo YA, Goodlett DR, Ochman H, Mougous JD, Goodman AL. Human symbionts inject and neutralize antibacterial toxins to persist in the gut. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 3639-3644. PMID: 26957597, PMCID: PMC4822603, DOI: 10.1073/pnas.1525637113.Peer-Reviewed Original ResearchConceptsHuman gut symbiontGut symbiontsMicrobial communitiesProminent Human Gut SymbiontHundreds of speciesHuman gut commensalGut microbial communityContact-dependent killingHuman gut microbiomeAntibacterial toxinsInterbacterial interactionsInteraction assaysCommunity compositionInterbacterial antagonismEffector lociImmunity genesMajor phylaSecretome studiesHuman symbiontsSymbiontsMicrobiome manipulationGut microbesGut commensalsMultiple mouse modelsGut microbiome
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