About
Research
Overview
Medical Research Interests
Immunotherapy
Publications
2023
A novel immune checkpoint score system for prognostic evaluation in pancreatic adenocarcinoma
Chen Y, Lin X, Zou X, Qian Y, Liu Y, Wang R, Wang X, Yu X, Liu C, Cheng H. A novel immune checkpoint score system for prognostic evaluation in pancreatic adenocarcinoma. BMC Gastroenterology 2023, 23: 113. PMID: 37024802, PMCID: PMC10080823, DOI: 10.1186/s12876-023-02748-w.Peer-Reviewed Original ResearchConceptsTumor-infiltrating immune cellsExpression of OX40Risk score modelImmune cellsIdentified OX40Immune checkpointsOverall survivalScoring systemRisk scoreClinical specimensExpression of immune checkpoint genesCD8+ T cellsImmune checkpoint gene expressionSomatic mutationsProtein expressionHigh-risk score groupImmunogenic cell deathCheckpoint gene expressionImmune checkpoint expressionImmune checkpoint genesImmune cell infiltrationNaive B cellsCox regression analysisAssociated with increased survival ratesRisk scoring systemAmbient oxygen levels regulate intestinal dysbiosis and GVHD severity after allogeneic stem cell transplantation
Seike K, Kiledal A, Fujiwara H, Henig I, Burgos da Silva M, van den Brink M, Hein R, Hoostal M, Liu C, Oravecz-Wilson K, Lauder E, Li L, Sun Y, Schmidt T, Shah Y, Jenq R, Dick G, Reddy P. Ambient oxygen levels regulate intestinal dysbiosis and GVHD severity after allogeneic stem cell transplantation. Immunity 2023, 56: 353-368.e6. PMID: 36736321, DOI: 10.1016/j.immuni.2023.01.007.Peer-Reviewed Original ResearchConceptsGraft-versus-host diseaseAmbient oxygen levelsGI graft-versus-host diseaseGut microbiome compositionMicrobiome-dependent mannerMicrobiome compositionMicrobial structureOxygen levelsIntestinal dysbiosisGraft-versus-host disease severityDysbiosisAllogeneic stem cell transplantationAnaerobic commensalsPathogenic T cellsStem cell transplantationIntestinal diseaseInflammatory bowel diseaseGastrointestinal (GI) diseasesCell transplantationIntestinal pathologyT cellsHostBowel diseaseHIF-1aIntestinal damageAssessing emotional characteristics in Asian autistic adults without intellectual disability
Chien Y, Liu C, Chiu Y, Lin C. Assessing emotional characteristics in Asian autistic adults without intellectual disability. Asian Journal Of Psychiatry 2023, 82: 103472. PMID: 36682157, DOI: 10.1016/j.ajp.2023.103472.Peer-Reviewed Original ResearchConceptsSchutte Emotional Intelligence ScaleAutistic adultsIntellectual disabilityEmotion perceptionSelf-reportEmotional Intelligence ScaleIntelligence ScaleMothers' reportsAutistic malesAutistic featuresEmotional characteristicsSchizophreniaEmotional featuresEmotionsAdultsDisabilitySchuttePerceptionScaleDifficultiesMale
2022
Esophageal Graft-vs-Host Disease Presenting as Esophagitis Dissecans Superficialis
Ogurick A, Liu C, Gowda L, Li D. Esophageal Graft-vs-Host Disease Presenting as Esophagitis Dissecans Superficialis. ACG Case Reports Journal 2022, 9: e00833. DOI: 10.14309/crj.0000000000000833.Peer-Reviewed Original ResearchNiacin skin flush and membrane polyunsaturated fatty acids in schizophrenia from the acute state to partial remission: a dynamic relationship
Yu Y, Su H, Lin S, Hsiao P, Lin Y, Liu C, Hwang T, Hsieh M, Liu C, Chien Y, Kuo C, Hwu H, Chen W. Niacin skin flush and membrane polyunsaturated fatty acids in schizophrenia from the acute state to partial remission: a dynamic relationship. Schizophrenia 2022, 8: 38. PMID: 35853900, PMCID: PMC9261101, DOI: 10.1038/s41537-022-00252-w.Peer-Reviewed Original ResearchSchizophrenia patientsMembrane polyunsaturated fatty acidsNiacin skin testFlushing responseArachidonic acid levelsArachidonic acidFollow-upIncreased turnover of arachidonic acidSkin testFlush scorePolyunsaturated fatty acidsVulnerability to schizophreniaTurnover of arachidonic acidDihomo-gamma-linolenic acidSchizophrenia inpatientsPartial remissionSchizophreniaAcute exacerbationSkin flushingHealthy controlsControl-to-case ratioPatientsPersistent decreaseDocosahexaenoic acidIncreased turnoverError patterns of facial emotion recognition in patients with schizophrenia
Lee S, Lin G, Shih C, Chen K, Liu C, Kuo C, Hsieh C. Error patterns of facial emotion recognition in patients with schizophrenia. Journal Of Affective Disorders 2022, 300: 441-448. PMID: 34979185, DOI: 10.1016/j.jad.2021.12.130.Peer-Reviewed Original ResearchConceptsFacial emotion recognitionNegative emotionsError patternsDifferentiation of facesDiscrimination of facesEmotion recognitionHealthy adultsHappy facesResponse biasSchizophreniaTraditional confusion matrixBasic emotionsFacial expressionsEmotionsMethodological issuesAdultsFaceDeficitsFindingsConfusion matrixCliniciansDiscriminationIndividualsInterventionRecognition
2021
WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway
Guo E, Xiao R, Wu Y, Lu F, Liu C, Yang B, Li X, Fu Y, Wang Z, Li Y, Huang Y, Li F, Wu X, You L, Qin T, Lu Y, Huang X, Ma D, Mills G, Sun C, Chen G. WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway. Journal Of Experimental Medicine 2021, 219: e20210789. PMID: 34825915, PMCID: PMC8628262, DOI: 10.1084/jem.20210789.Peer-Reviewed Original ResearchMeSH KeywordsA549 CellsAnimalsAntineoplastic Combined Chemotherapy ProtocolsCD8-Positive T-LymphocytesCell Cycle ProteinsCell Line, TumorEndogenous RetrovirusesEnzyme InhibitorsFemaleGene Expression Regulation, NeoplasticHCT116 CellsHumansImmune Checkpoint InhibitorsMice, Inbred BALB CMice, Inbred C57BLMice, Inbred NODMice, SCIDNeoplasms, ExperimentalProtein-Tyrosine KinasesPyrazolesPyrimidinonesRNA, Double-StrandedSignal TransductionTumor BurdenConceptsImmune checkpoint blockadeAnti-tumor immunityEndogenous retroviral elementsWEE1 inhibitionCheckpoint blockadeCD8+ T cell-dependent mannerSensitivity to immune checkpoint blockadeResponse to immune checkpoint blockadeAnti-tumor T cellsCombination of WEE1 inhibitorT cell-dependent mannerPathway-targeted therapiesMultiple tumor modelsPopulation of patientsEmergence of resistanceDown-regulating FoxM1Viral defense pathwaysPD-L1Tumor regressionCombination therapyTargeted therapyCombination partnerT cellsPatient selectionWEE1 inhibitorImmune-Mediated Reprogramming of Intestinal Stem Cells Drives STAT1-Dependent Myc Expression and Epithelial Regeneration in GI-Gvhd
Takashima S, Sharma R, Egorova A, Kuttiyara J, Ito T, Chang W, Jansen S, Liu C, Lindemans C, Mazutis L, Robine N, Hanash A. Immune-Mediated Reprogramming of Intestinal Stem Cells Drives STAT1-Dependent Myc Expression and Epithelial Regeneration in GI-Gvhd. Blood 2021, 138: 86-86. DOI: 10.1182/blood-2021-152647.Peer-Reviewed Original ResearchIntestinal stem cellsGene set enrichment analysisMYC expressionIFNG treatmentSTAT1-dependent mannerActivating myc expressionDownstream of Wnt signalingInduced epithelial apoptosisInhibitor 10058-F4Intestinal stem cell maintenanceMYC inhibitor 10058-F4Single cell RNA sequencingIFNG signalingIntestinal stem cell populationIntestinal cryptsCell RNA sequencingGene expression profilesCell cycle analysisUpregulated transcription factorsWnt target gene Axin2Myc functionUpregulation of cyclin D1Sequenced cellsMYC pathwayPhenotypic distancesA quarter of century after: The changing ecology of psychiatric emergency services
Chen W, Hsieh M, Liao S, Liu C, Liu C, Wu C, Lin Y, Hwang T, Chien Y. A quarter of century after: The changing ecology of psychiatric emergency services. Asia-Pacific Psychiatry 2021, 14: e12487. PMID: 34510765, DOI: 10.1111/appy.12487.Peer-Reviewed Original ResearchConceptsMental disordersPsychiatry consultationSuicide/self-harmStressor-related disordersEmergency psychiatric servicesEmergency psychiatry serviceClinical data of genderCommon mental disordersSchizophrenia spectrumEmergency departmentPsychotic disordersDepressive disorderBipolar disorderPsychiatric servicesPsychiatry servicesPsychiatric emergenciesDisordersClinical trainingPsychiatryNeurosisChief complaintED visitsSchizophreniaMedical CenterData of genderThe Diversity of Vaginal Microbiota Predicts Neoadjuvant Chemotherapy Responsiveness in Locally Advanced Cervical Cancer
Wang Z, Xiao R, Huang J, Qin X, Hu D, Guo E, Liu C, Lu F, You L, Sun C, Chen G. The Diversity of Vaginal Microbiota Predicts Neoadjuvant Chemotherapy Responsiveness in Locally Advanced Cervical Cancer. Microbial Ecology 2021, 84: 302-313. PMID: 34405250, DOI: 10.1007/s00248-021-01800-0.Peer-Reviewed Original ResearchConceptsLocally advanced cervical cancerLocally advanced cervical cancer patientsPlatinum-based chemotherapy responseAdvanced cervical cancerCervical cancerChemotherapy responseAlpha diversityVaginal microbiotaVaginal samplesCC patientsVaginal microbiomeHealthy controlsPredicting neoadjuvant chemotherapy responsePlatinum-resistant patientsNeoadjuvant chemotherapy responseAssociated with platinum-based chemotherapy responseCervical cancer patientsVaginal microbiota diversityNeoadjuvant chemotherapyHPV infectionBeta diversityBacteroides genusChemotherapy effectCancer patientsBacteroides abundance
Academic Achievements & Community Involvement
Clinical Care
Overview
Chen Liu, MD, PhD, is a pathologist who specializes in the study and treatment of viral hepatitis and liver cancer. He focuses on understanding how the immune system can be harnessed to treat liver cancer and explores the role of genetic changes in cancer development.
Dr. Liu is also involved in researching graft-versus-host disease, a condition that can occur after a bone marrow transplant. He offers diagnostic services that help in the management of these complex conditions, using a variety of laboratory techniques to analyze tissue samples and provide accurate diagnoses.
As the Anthony N. Brady Professor of Pathology at Yale School of Medicine, Dr. Liu is engaged in research on immunotherapy, which seeks to use the body's immune system to fight cancer. His work aims to develop new strategies to improve patient outcomes in liver cancer and other diseases.
Dr. Liu completed his medical training at Tong Liao Medical College in China and received his doctoral degree in pathology from the University of Pennsylvania School of Medicine. He furthered his expertise through residency training in anatomical and clinical pathology at the Medical College of Pennsylvania and an oncological pathology fellowship at M.D. Anderson Cancer Hospital.
Clinical Specialties
Pathology
Fact Sheets
Hyperthermic Intraperitoneal Chemotherapy (HIPEC)
Learn More on Yale MedicineGastrointestinal Cancers
Learn More on Yale Medicine
Board Certifications
Anatomic & Clinical Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 2000
Yale Medicine News
News & Links
News
- April 01, 2025
Joshua Warrick, MD, to Succeed Peter Humphrey, MD, PhD, as Director of Genitourinary Pathology
- March 27, 2025
Yale Pathologists Share Insight, Latest Research at USCAP 2025
- November 13, 2024
Public School Students Explore Careers at Annual Yale Pathology Day
- September 25, 2024
David Klimstra, MD, Joins Yale School of Medicine as a Professor of Pathology