2022
Hemodynamic differences between women and men with elevated blood pressure in China: A non-invasive assessment of 45,082 adults using impedance cardiography
Caraballo C, Mahajan S, Gu J, Lu Y, Spatz ES, Dreyer RP, Zhang M, Sun N, Ren Y, Zheng X, Zhao H, Lu H, J. Z, Krumholz HM. Hemodynamic differences between women and men with elevated blood pressure in China: A non-invasive assessment of 45,082 adults using impedance cardiography. PLOS ONE 2022, 17: e0269777. PMID: 35700163, PMCID: PMC9197037, DOI: 10.1371/journal.pone.0269777.Peer-Reviewed Original ResearchConceptsElevated blood pressureSystemic vascular resistance indexVascular resistance indexBlood pressureCardiac indexResistance indexHigh systemic vascular resistance indexLower systemic vascular resistance indexHigher mean systolic blood pressureMean diastolic blood pressureMean systolic blood pressureImpedance cardiographyLow cardiac indexHigher cardiac indexDiastolic blood pressureSystolic blood pressureBody mass indexYear old womanPersonalization of treatmentSame age groupNon-invasive assessmentSex differencesHemodynamic profileMass indexHemodynamic differences
2020
Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program
Klarin D, Verma S, Judy R, Dikilitas O, Wolford B, Paranjpe I, Levin M, Pan C, Tcheandjieu C, Spin J, Lynch J, Assimes T, Åldstedt Nyrønning L, Mattsson E, Edwards T, Denny J, Larson E, Lee M, Carrell D, Zhang Y, Jarvik G, Gharavi A, Harley J, Mentch F, Pacheco J, Hakonarson H, Skogholt A, Thomas L, Gabrielsen M, Hveem K, Nielsen J, Zhou W, Fritsche L, Huang J, Natarajan P, Sun Y, DuVall S, Rader D, Cho K, Chang K, Wilson P, O’Donnell C, Kathiresan S, Scali S, Berceli S, Willer C, Jones G, Bown M, Nadkarni G, Kullo I, Ritchie M, Damrauer S, Tsao P, Gaziano J, Ramoni R, Beckham J, Breeling J, Chang K, Huang G, Muralidhar S, O’Donnell C, Casas Romero J, Tsao P, Muralidhar S, Moser J, Whitbourne S, Brewer J, Concato J, Warren S, Argyres D, Tsao P, Gaziano J, Stephens B, Brophy M, Humphries D, Do N, Shayan S, Nguyen X, O’Donnell C, Pyarajan S, Tsao P, Cho K, Pyarajan S, Hauser E, Sun Y, Zhao H, Wilson P, McArdle R, Dellitalia L, Harley J, Zablocki C, Whittle J, Beckham J, Wells J, Gutierrez S, Gibson G, Kaminsky L, Villareal G, Kinlay S, Xu J, Hamner M, Haddock K, Bhushan S, Iruvanti P, Godschalk M, Ballas Z, Buford M, Mastorides S, Klein J, Ratcliffe N, Florez H, Swann A, Murdoch M, Sriram P, Yeh S, Washburn R, Jhala D, Aguayo S, Cohen D, Sharma S, Callaghan J, Oursler K, Whooley M, Ahuja S, Gutierrez A, Schifman R, Greco J, Rauchman M, Servatius R, Oehlert M, Wallbom A, Fernando R, Morgan T, Stapley T, Sherman S, Anderson G, Tsao P, Sonel E, Boyko E, Meyer L, Gupta S, Fayad J, Hung A, Lichy J, Hurley R, Robey B, Striker R. Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program. Circulation 2020, 142: 1633-1646. PMID: 32981348, PMCID: PMC7580856, DOI: 10.1161/circulationaha.120.047544.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmBlood pressurePolygenic risk scoresAortic aneurysmFamily historyDiastolic blood pressureSystolic blood pressureGenome-wide polygenic risk scoreRisk variantsSmoking risk factorsMendelian randomization analysisAAA prevalenceCardiovascular mortalityRisk factorsAAA developmentArterial bedCurrent guidelinesVascular territoriesLower extremitiesMillion Veteran ProgramRisk scoreTherapeutic implicationsCurrent screeningImportant causeAAA risk
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