Won Jae Huh, MD, PhD
Assistant Professor of PathologyCards
About
Research
Overview
Medical Research Interests
Cell Dedifferentiation; Cell Differentiation; Cell Plasticity; EGF Family of Proteins; Liver; Metaplasia; Stem Cells; Stomach; Stomach Neoplasms
Publications
2025
711 Gastric Adenocarcinoma in Autoimmune Atrophic Gastritis: Clinicopathologic Study of 18 Cases with Focus on Pyloric Gland Type Adenocarcinoma
Wang X, Jiao J, Huh W, Zhang X. 711 Gastric Adenocarcinoma in Autoimmune Atrophic Gastritis: Clinicopathologic Study of 18 Cases with Focus on Pyloric Gland Type Adenocarcinoma. Laboratory Investigation 2025, 105: 102942. DOI: 10.1016/j.labinv.2024.102942.Peer-Reviewed Original Research604 Whole Exome Sequencing Reveals Genetic Alterations Involving MEN1 as a Potential Mechanism of Wnt Signaling Activation in Gastric Adenocarcinoma of the Fundic Gland Type
Huh W, Bearse M, Finberg K, Jain D. 604 Whole Exome Sequencing Reveals Genetic Alterations Involving MEN1 as a Potential Mechanism of Wnt Signaling Activation in Gastric Adenocarcinoma of the Fundic Gland Type. Laboratory Investigation 2025, 105: 102835. DOI: 10.1016/j.labinv.2024.102835.Peer-Reviewed Original Research
2024
Arsenic and young liver: a case report of hepatic steatosis due to arsenic toxicity
Nguyen C, Alvarado M, Huh W, Batisti J. Arsenic and young liver: a case report of hepatic steatosis due to arsenic toxicity. Clinical Journal Of Gastroenterology 2024, 18: 114-118. PMID: 39377877, DOI: 10.1007/s12328-024-02045-3.Peer-Reviewed Original ResearchPD-1H/VISTA Agonism Inhibits Host Myeloid Antigen Presenting Cells That Suppresses Acute Graft-Versus-Host Disease without Losing Graft-Versus-Leukemia Effect
Hu Q, Fielder C, Huh W, Kassim A, Kim T. PD-1H/VISTA Agonism Inhibits Host Myeloid Antigen Presenting Cells That Suppresses Acute Graft-Versus-Host Disease without Losing Graft-Versus-Leukemia Effect. Transplantation And Cellular Therapy 2024, 30: s253. DOI: 10.1016/j.jtct.2023.12.336.Peer-Reviewed Original ResearchMyeloid antigen-presenting cellsHost antigen-presenting cellsAntigen-presenting cellsBone marrow transplantationMyeloid-derived suppressor cellsAllogeneic T cell proliferationAcute GVHDAcute GVHD symptomsGraft-versus-leukemiaPD-1HT cell proliferationHost miceT cellsBMT modelIsotype controlGraft-versus-leukemia (GVLSuppress acute graft-versus-host diseaseMHC-mismatched bone marrow transplantationAcute graft-versus-host diseaseT cell priming phaseGraft-versus-host diseaseMismatched bone marrow transplantationMyeloid antigen presenting cellsAcute GVHD treatmentDonor T cells
2023
VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis.
Kim S, Adams T, Hu Q, Shin H, Chae G, Lee S, Sharma L, Kwon H, Lee F, Park H, Huh W, Manning E, Kaminski N, Sauler M, Chen L, Song J, Kim T, Kang M. VISTA (PD-1H) Is a Crucial Immune Regulator to Limit Pulmonary Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2023, 69: 22-33. PMID: 36450109, PMCID: PMC10324045, DOI: 10.1165/rcmb.2022-0219oc.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisImmune regulatorsTherapeutic potentialHuman idiopathic pulmonary fibrosisCrucial immune regulatorsNovel immune regulatorPulmonary fibrosis micePulmonary fibrosis modelNovel therapeutic targetRole of VISTAWild-type littermatesMonocyte-derived macrophagesT lymphocyte lineageVISTA expressionIPF treatmentAntibody treatmentImmune landscapeFibrotic mediatorsLung fibrosisFibrosis miceInflammatory responseFibrosis modelMyeloid populationsTherapeutic targetSOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia
Willet S, Thanintorn N, McNeill H, Huh S, Ornitz D, Huh W, Hoft S, DiPaolo R, Mills J. SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia. Cellular And Molecular Gastroenterology And Hepatology 2023, 16: 325-339. PMID: 37270061, PMCID: PMC10444955, DOI: 10.1016/j.jcmgh.2023.05.009.Peer-Reviewed Original ResearchConceptsSRY-box transcription factor 9Cell identityAdult homeostasisGastric progenitorsMucous neck cellsZymogenic chief cellsGastric developmentNeck cellsPotential genesMaster regulatorExpression patternsGene expressionSPEM cellsCell differentiationCorpus unitsSOX9 expressionSOX9Factor 9Specific expansionHomeostasisMisexpressionSox9 deletionReprogrammingChief cellsGenetic deletionIntra-Abdominal Cystic Lymphangiomas: The Vanderbilt Experience
Mede A, Chotai P, Huh W, Tan M. Intra-Abdominal Cystic Lymphangiomas: The Vanderbilt Experience. Journal Of Surgical Research 2023, 285: 197-204. PMID: 36696706, DOI: 10.1016/j.jss.2022.12.026.Peer-Reviewed Case Reports and Technical NotesConceptsAbdominal lymphangiomaSmall bowelExtensive local invasionTime of diagnosisDiagnosis of lymphangiomaInstitutional review boardVanderbilt experienceAbdominal painMultivisceral resectionMedian durationMost patientsClinical featuresFavorable prognosisRetrospective reviewCystic tumorHistopathologic characteristicsInstitution experienceSurgical excisionSymptomatic lesionsMean ageMural nodulesPreoperative imagingRare pathologyExcisional biopsyIncomplete excision
2021
Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps
Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell 2021, 184: 6262-6280.e26. PMID: 34910928, PMCID: PMC8941949, DOI: 10.1016/j.cell.2021.11.031.Peer-Reviewed Original ResearchMeSH KeywordsAdaptive ImmunityAdenomaAdultAgedAnimalsCarcinogenesisCell DeathCell DifferentiationColonic PolypsColorectal NeoplasmsDisease ProgressionFemaleGene Expression Regulation, NeoplasticGene Regulatory NetworksGenetic HeterogeneityHumansMaleMiceMiddle AgedMutationNeoplastic Stem CellsReproducibility of ResultsRNA-SeqSingle-Cell AnalysisTumor MicroenvironmentConceptsHuman colorectal polypsColorectal cancerColorectal polypsPrevention of CRCMicrosatellite-unstable colorectal cancersUnstable colorectal cancersGastric metaplasiaImmune microenvironmentTumor cell differentiation statusImmune cellsPrecision surveillancePrecursor polypsSerrated polypsConventional adenomasStem cell propertiesMalignant progressionImmunogenic potentialPolypsTumor cellsTherapeutic insightsCell differentiation statusCellular originMetaplasiaAdenomasMolecular heterogeneitySupermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ. Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets. Nature Cell Biology 2021, 23: 1240-1254. PMID: 34887515, PMCID: PMC8656144, DOI: 10.1038/s41556-021-00805-8.Peer-Reviewed Original ResearchConceptsSmall extracellular vesiclesTherapeutic targetExtracellular vesiclesHepatic lipidsCardiovascular diseaseCetuximab resistanceMultiple cancersAlzheimer's diseaseDiseaseLactate secretionDisease biomarkersBiomarkersExtracellular RNAIntense investigationHuman diseasesGreater uptakeVivoCancerSecretionCell-Autonomous Role of EGFR in Spontaneous Duodenal Tumors in LRIG1 Null Mice
Niitsu H, Lu Y, Huh W, Love A, Franklin J, Coffey R. Cell-Autonomous Role of EGFR in Spontaneous Duodenal Tumors in LRIG1 Null Mice. Cellular And Molecular Gastroenterology And Hepatology 2021, 12: 1159-1162.e4. PMID: 33989815, PMCID: PMC8413138, DOI: 10.1016/j.jcmgh.2021.05.004.Peer-Reviewed Original Research
Clinical Care
Overview
Won Jae Huh, MD, PhD, is a pathologist who specializes in diagnosing and evaluating conditions involving the gastrointestinal tract and liver. He works closely with patients to understand changes in tissue structure and identify signs of disease, including inflammation or abnormal growths.
As an assistant professor of pathology at Yale School of Medicine, Dr. Huh conducts research on cellular changes in pre-cancerous stomach lesions and mucosal injuries. His work explores how cells in the stomach can transform in response to injury or disease, aiming to uncover pathways that could lead to new treatments.
Additionally, Dr. Huh investigates the role of testosterone in regulating epidermal growth factor receptor protein levels in the liver, which may contribute to differences between men and women in liver diseases such as fatty liver disease and hepatocellular carcinoma.
“My career goal is to better understand signal pathways that regulate tissue regeneration and early tumorigenesis with the intention of discovering new therapeutics that can facilitate regeneration and prevent tumor formation,” he says.
Dr. Huh received his medical training from Seoul National University College of Medicine in South Korea and pursued residency in anatomic pathology at Montefiore Medical Center/Albert Einstein College of Medicine. He completed a fellowship in gastrointestinal and liver pathology at Vanderbilt University Medical Center.
Clinical Specialties
Pathology; GI & Liver Pathology
News
News
- July 22, 2022
Huh Lab Welcomes Newest Postdoctoral Associate, Miyoung Shin, PhD
- April 19, 2022
Tryston Gabriel, New Postgraduate Associate in Huh Lab
- April 12, 2022
Yale Pathology Meets in Madison for Department Retreat; First In-Person Gathering Since Pandemic Began
- January 17, 2022
Huh Lab Seeks Applicants for Postdoctoral, Postgraduate Associate Positions
Get In Touch
Contacts
Email
Administrative Support
Locations
Brady Memorial Laboratory
Lab
310 Cedar Street, Rm BML 142
New Haven, CT 06510
Lauder Hall
Academic Office
310 Cedar Street, Rm LH 219A
New Haven, CT 06510
Business Office
203.785.7308Patient Care Locations
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