2022
Mildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions
Brenes D, Nipper A, Tan M, Gleber-Netto F, Schwarz R, Pickering C, Williams M, Vigneswaran N, Gillenwater A, Sikora A, Richards-Kortum R. Mildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions. Oral Oncology 2022, 135: 106232. PMID: 36335817, PMCID: PMC9881670, DOI: 10.1016/j.oraloncology.2022.106232.Peer-Reviewed Original ResearchConceptsOral premalignant lesionsMild dysplasiaSevere dysplasiaOral lesionsPremalignant lesionsDysplastic oral lesionsHigh-grade pathologySubset of lesionsLoss of autofluorescenceDysplastic lesionsOptical imaging studiesOral surgeryDysplasiaDetectable abnormalitiesPatient careLesionsImaging studiesEpithelial cell nucleiPatientsGene expressionGene expression profilesMarkersGene expression analysisSimilar gene expressionExpression profiles
2018
Risk Stratification of Oral Potentially Malignant Disorders in Fanconi Anemia Patients Using Autofluorescence Imaging and Cytology-On-A Chip Assay
Abram TJ, Pickering CR, Lang AK, Bass NE, Raja R, Meena C, Alousi AM, Myers JN, McDevitt JT, Gillenwater AM, Vigneswaran N. Risk Stratification of Oral Potentially Malignant Disorders in Fanconi Anemia Patients Using Autofluorescence Imaging and Cytology-On-A Chip Assay. Translational Oncology 2018, 11: 477-486. PMID: 29481998, PMCID: PMC5884187, DOI: 10.1016/j.tranon.2018.01.014.Peer-Reviewed Original ResearchOral squamous cell carcinomaFanconi anemiaHematopoietic stem cell transplantationFA patientsGenomic instability disorderHigh-risk OPMDsLoss of autofluorescenceExpression levelsHSCT statusNext-generation sequencingFanconi anemia patientsMalignant disordersRisk of OSCCFAT1 geneCellular morphometryBone marrow failureClinical risk indicatorsStem cell transplantationSquamous cell carcinomaBrush biopsy samplesUse of COCsLong-term surveillanceHigh-risk indicatorsWhite blood cellsInvasive diagnostic tool