Projects

PROJECT 1: Improved targeting of EGFR family members in squamous cell carcinomas of the head and neck
The epidermal growth factor receptor (EGFR) remains the only validated molecular target in head and neck squamous cell carcinoma (HNSCC), mediating cell survival signaling and resistance to radiation therapy.
PROJECT 2: Synthetic lethal therapy for HPV-negative head and neck cancer
HPV-negative head and neck squamous cell carcinomas (HNSCC) typically lose G1/S cell cycle checkpoints, with most tumors having mutations in TP53, and many also mutating other tumor suppressors such as CDKN2A.
PROJECT 3: Demethylation of HPV-associated head and neck cancer to trigger APOBEC synthetic lethality and enhance immune response
Human papillomavirus (HPV)-associated neck squamous cell carcinoma (HNSCC) represents an increasing proportion of HNSCC.

PROJECT 1: Improved targeting of EGFR family members in squamous cell carcinomas of the head and neck