2014
Key tumor suppressor genes inactivated by “greater promoter” methylation and somatic mutations in head and neck cancer
Guerrero-Preston R, Michailidi C, Marchionni L, Pickering CR, Frederick MJ, Myers JN, Yegnasubramanian S, Hadar T, Noordhuis MG, Zizkova V, Fertig E, Agrawal N, Westra W, Koch W, Califano J, Velculescu VE, Sidransky D. Key tumor suppressor genes inactivated by “greater promoter” methylation and somatic mutations in head and neck cancer. Epigenetics 2014, 9: 1031-1046. PMID: 24786473, PMCID: PMC4143405, DOI: 10.4161/epi.29025.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Squamous CellCell Line, TumorCohort StudiesCpG IslandsDNA MethylationFemaleGene SilencingGenes, Tumor SuppressorHead and Neck NeoplasmsHumansMaleMutationPaired Box Transcription FactorsPAX5 Transcription FactorPromoter Regions, GeneticReceptor, Notch1Tumor Suppressor Protein p53ConceptsKey tumor suppressor genesTumor suppressor geneSuppressor geneRecent high-throughput genomic studiesSomatic mutationsPromoter methylationWhole genome gene expression arraysHigh-throughput genomic studiesPax gene familyNovel tumor suppressor geneIntegrated molecular analysisSpecific promoter methylationK methylation arrayGene expression arraysGenome maintenanceEpigenomic levelsGene familyCell fateGenomic studiesDownregulated genesTranscription factorsCanonical NotchEpigenomic alterationsDomain sequencingMethylation arrays
2013
FXR silencing in human colon cancer by DNA methylation and KRAS signaling
Bailey AM, Zhan L, Maru D, Shureiqi I, Pickering CR, Kiriakova G, Izzo J, He N, Wei C, Baladandayuthapani V, Liang H, Kopetz S, Powis G, Guo GL. FXR silencing in human colon cancer by DNA methylation and KRAS signaling. AJP Gastrointestinal And Liver Physiology 2013, 306: g48-g58. PMID: 24177031, PMCID: PMC3920083, DOI: 10.1152/ajpgi.00234.2013.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaBile Acids and SaltsCarcinogenesisCell Line, TumorColonColonic NeoplasmsColonic PolypsDNA MethylationEpithelial-Mesenchymal TransitionGene SilencingHumansNeoplasm StagingProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)Ras ProteinsReceptors, Cytoplasmic and NuclearSignal TransductionConceptsDNA methylationHuman colon cancerHuman colon cancer progressionMethyl-DNA immunoprecipitationRegulation of FXRFarnesoid X receptorMesenchymal transitionOncogenic signaling cascadesMouse knockout studiesReverse phase protein arrayColon cancer progressionDNA methyltransferase inhibitionFunction of FXRCancer Genome Atlas (TCGA) samplesColon cancer cell linesColon cancer samplesCancer Genome AtlasBisulfite sequencingMethylation patternsKnockout studiesColon cancer developmentSignaling cascadesMethyltransferase inhibitionTumor suppressorPhosphatidylinositol 4