2007
Assessment of PI3 kinase as a druggable target in melanoma
Aziz S, Pick-Golan E, McCarthy M, Flaherty K, Camp R, Rimm D, Kluger H. Assessment of PI3 kinase as a druggable target in melanoma. Journal Of Clinical Oncology 2007, 25: 8521-8521. DOI: 10.1200/jco.2007.25.18_suppl.8521.Peer-Reviewed Original ResearchPI3-kinaseKinase expressionDrug targetsIntracellular signal transduction pathwaysNumerous cellular functionsSignal transduction pathwaysMajor intracellular signal transduction pathwaysPI3-kinase inhibitorAttractive drug targetValuable drug targetsCellular functionsTransduction pathwaysDifferential expressionBenign neviKinaseDruggable targetsExpression levelsProtein levelsMalignant melanocytesKinase inhibitorsDisease aggressionExpressionMalignant cellsPrimary specimensTarget
2004
Technology Insight: identification of biomarkers with tissue microarray technology
Giltnane JM, Rimm DL. Technology Insight: identification of biomarkers with tissue microarray technology. Nature Reviews Clinical Oncology 2004, 1: 104-111. PMID: 16264828, DOI: 10.1038/ncponc0046.Peer-Reviewed Original ResearchConceptsMicroarray technologyRate of translationGene expression microarraysHigh-throughput technologiesTumor-specific protein expressionHigh-throughput analysisExpression microarraysTarget discoveryTissue microarray technologyMicroarrayProtein expressionPotential targetIdentification of biomarkersTissue microarrayBiomedical researchTargetPowerful toolTranslationExpressionQuality controlRapid mannerDiscovery