2021
Chemotherapy-related amenorrhea (CRA) after adjuvant ado-trastuzumab emtansine (T-DM1) compared to paclitaxel in combination with trastuzumab (TH) (TBCRC033: ATEMPT Trial)
Ruddy KJ, Zheng Y, Tayob N, Hu J, Dang CT, Yardley DA, Isakoff SJ, Valero VV, Faggen MG, Mulvey TM, Bose R, Sella T, Weckstein DJ, Wolff AC, Reeder-Hayes KE, Rugo HS, Ramaswamy B, Zuckerman DS, Hart LL, Gadi VK, Constantine M, Cheng KL, Briccetti FM, Schneider BP, Merrill Garrett A, Kelly Marcom P, Albain KS, DeFusco PA, Tung NM, Ardman BM, Nanda R, Jankowitz RC, Rimawi M, Abramson V, Pohlmann PR, Van Poznak C, Forero-Torres A, Liu MC, Rosenberg S, DeMeo MK, Burstein HJ, Winer EP, Krop IE, Partridge AH, Tolaney SM. Chemotherapy-related amenorrhea (CRA) after adjuvant ado-trastuzumab emtansine (T-DM1) compared to paclitaxel in combination with trastuzumab (TH) (TBCRC033: ATEMPT Trial). Breast Cancer Research And Treatment 2021, 189: 103-110. PMID: 34120223, DOI: 10.1007/s10549-021-06267-8.Peer-Reviewed Original ResearchConceptsChemotherapy-related amenorrheaEarly-stage breast cancerRisk of infertilityAdo-trastuzumab emtansineT-DM1Gonadotropin-releasing hormone agonistAdjuvant T-DM1T-DM1 3.6Amenorrhea ratesPermanent menopauseStandard HER2Chemotherapy regimensPrimary endpointProtocol therapyMedian ageOvarian toxicityPremature menopauseHormone agonistBreast cancerMenstrual dataMonthsAmenorrheaEmtansineMenopauseTrastuzumab
2007
Age of menopause among women who remain premenopausal following treatment for early breast cancer: Long-term results from International Breast Cancer Study Group Trials V and VI
Partridge A, Gelber S, Gelber RD, Castiglione-Gertsch M, Goldhirsch A, Winer E. Age of menopause among women who remain premenopausal following treatment for early breast cancer: Long-term results from International Breast Cancer Study Group Trials V and VI. European Journal Of Cancer 2007, 43: 1646-1653. PMID: 17512721, DOI: 10.1016/j.ejca.2007.04.006.Peer-Reviewed Original ResearchConceptsCycles of CMFInternational Breast Cancer Study Group Trial VBreast cancerPremature menopauseCox proportional hazards modelTrial VEarly breast cancerLong-term resultsAge of menopauseProportional hazards modelAdjuvant chemotherapyMenses dataTemporary amenorrheaBilateral oophorectomyPremenopausal womenNode negativeSystemic therapyChemotherapyHazards modelMenopauseTrial VIEarly onsetWomenCancerTemporary cessation
2005
Delayed premature menopause following chemotherapy for early stage breast cancer: Long-term results from IBCSG Trial V
Partridge A, Gelber S, Gelber R, Goldhirsch A, Winer E. Delayed premature menopause following chemotherapy for early stage breast cancer: Long-term results from IBCSG Trial V. Journal Of Clinical Oncology 2005, 23: 687-687. DOI: 10.1200/jco.2005.23.16_suppl.687.Peer-Reviewed Original Research