2019
Modelling microbial infection to address global health challenges
Fitzpatrick MC, Bauch CT, Townsend JP, Galvani AP. Modelling microbial infection to address global health challenges. Nature Microbiology 2019, 4: 1612-1619. PMID: 31541212, PMCID: PMC6800015, DOI: 10.1038/s41564-019-0565-8.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsCommunicable Disease ControlCommunicable DiseasesCommunicable Diseases, EmergingData CollectionDecision MakingGlobal HealthHumansModels, BiologicalPandemicsConceptsOptimization of modelsGlobal health challengeDisease transmission dynamicsHealth challengesEpidemiological modellingAccuracy of predictionDifferent intervention strategiesPandemic preparednessInfectious diseasesTransmission dynamicsMicrobial infectionsIntervention strategiesModel developmentPublic healthDiseaseHIV crisisModelOptimizationRiskHealthDynamicsModellingClose collaborationMethodological advancesModelers
2016
One Health approach to cost-effective rabies control in India
Fitzpatrick MC, Shah HA, Pandey A, Bilinski AM, Kakkar M, Clark AD, Townsend JP, Abbas SS, Galvani AP. One Health approach to cost-effective rabies control in India. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 14574-14581. PMID: 27994161, PMCID: PMC5187709, DOI: 10.1073/pnas.1604975113.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBites and StingsCommunicable Disease ControlCost-Benefit AnalysisDemographyDog DiseasesDogsFemaleHealth Care CostsHumansIndiaMaleOne HealthRabiesSensitivity and SpecificityVaccinationConceptsHuman rabiesRabies deathsCanine vaccinationStray dogsHuman rabies deathsRabies controlCost-effectiveness thresholdPostexposure vaccinationWHO criteriaDog bitesAutopsy dataHealth outcomesHealth approachSurveillance dataVaccinationCost-effective strategyDogsRabiesRabies surveillance dataOne-thirdQuantifying Transmission of Clostridium difficile within and outside Healthcare Settings
Durham DP, Olsen MA, Dubberke ER, Galvani AP, Townsend JP. Quantifying Transmission of Clostridium difficile within and outside Healthcare Settings. Emerging Infectious Diseases 2016, 22: 608-616. PMID: 26982504, PMCID: PMC4806959, DOI: 10.3201/eid2204.150455.Peer-Reviewed Original ResearchConceptsClostridium difficile infectionAsymptomatic carriersLong-term care facility settingLong-term care facility residentsHospital-onset Clostridium difficile infectionCare facility residentsEffect of hospitalCommunity-based transmissionCommunity sourcesAsymptomatic patientsCDI incidenceDifficile infectionFacility residentsPatientsControl interventionsDifficile prevalenceC. difficileClostridium difficileHealthcare settingsNational databaseQuantifying transmissionTransmission routesHospitalDifficileControl measuresDeterminants of Human African Trypanosomiasis Elimination via Paratransgenesis
Gilbert JA, Medlock J, Townsend JP, Aksoy S, Mbah M, Galvani AP. Determinants of Human African Trypanosomiasis Elimination via Paratransgenesis. PLOS Neglected Tropical Diseases 2016, 10: e0004465. PMID: 26954675, PMCID: PMC4783105, DOI: 10.1371/journal.pntd.0004465.Peer-Reviewed Original Research
2015
Quantitative analyses and modelling to support achievement of the 2020 goals for nine neglected tropical diseases
Hollingsworth TD, Adams ER, Anderson RM, Atkins K, Bartsch S, Basáñez MG, Behrend M, Blok DJ, Chapman LA, Coffeng L, Courtenay O, Crump RE, de Vlas SJ, Dobson A, Dyson L, Farkas H, Galvani AP, Gambhir M, Gurarie D, Irvine MA, Jervis S, Keeling MJ, Kelly-Hope L, King C, Lee BY, Le Rutte EA, Lietman TM, Ndeffo-Mbah M, Medley GF, Michael E, Pandey A, Peterson JK, Pinsent A, Porco TC, Richardus JH, Reimer L, Rock KS, Singh BK, Stolk W, Swaminathan S, Torr SJ, Townsend J, Truscott J, Walker M, Zoueva A, NTD Modelling Consortium. Quantitative analyses and modelling to support achievement of the 2020 goals for nine neglected tropical diseases. Parasites & Vectors 2015, 8: 630. PMID: 26652272, PMCID: PMC4674954, DOI: 10.1186/s13071-015-1235-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsBiostatisticsCommunicable Disease ControlDisease EradicationDisease Transmission, InfectiousEpidemiologic MethodsHumansModels, TheoreticalNeglected DiseasesConceptsTropical diseasesTrue eliminationPublic health problemSoil-transmitted helminthsPersistence of diseaseSuccess of interventionsHigh riskVisceral leishmaniasisDynamics of transmissionHuman African trypanosomiasisHealth problemsEpidemiological settingsDiseaseLymphatic filariasisChagas diseaseControl initiativesAfrican trypanosomiasisInfectionInterventionUrgent needDetailed adviceSchistosomiasisTrachomaLeishmaniasisElimination
2013
Cost-effectiveness of a community-based intervention for reducing the transmission of Schistosoma haematobium and HIV in Africa
Mbah M, Kjetland EF, Atkins KE, Poolman EM, Orenstein EW, Meyers LA, Townsend JP, Galvani AP. Cost-effectiveness of a community-based intervention for reducing the transmission of Schistosoma haematobium and HIV in Africa. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 7952-7957. PMID: 23589884, PMCID: PMC3651507, DOI: 10.1073/pnas.1221396110.Peer-Reviewed Original ResearchConceptsCommunity-based interventionsHIV infectionHIV transmissionSchistosoma haematobiumFemale genital schistosomiasisAdministration of praziquantelSaharan AfricaRural ZimbabweS. haematobium transmissionGenital schistosomiasisGenital infectionHealth payersSchool-aged childrenIntervention periodEpidemiological dataEpidemiological studiesS. haematobiumSchistosomiasis prevalenceHealth educationInfectionSchistosomiasisYoung womenHaematobiumInterventionHIV