Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells
Lopez-Sambrooks C, Shrimal S, Khodier C, Flaherty DP, Rinis N, Charest JC, Gao N, Zhao P, Wells L, Lewis TA, Lehrman MA, Gilmore R, Golden JE, Contessa JN. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nature Chemical Biology 2016, 12: 1023-1030. PMID: 27694802, PMCID: PMC5393272, DOI: 10.1038/nchembio.2194.Peer-Reviewed Original ResearchMeSH KeywordsBenzamidesCell Cycle CheckpointsCell Line, TumorCell ProliferationCellular SenescenceDose-Response Relationship, DrugEnzyme InhibitorsHexosyltransferasesHigh-Throughput Screening AssaysHumansMembrane ProteinsMolecular StructureReceptor Protein-Tyrosine KinasesStructure-Activity RelationshipSulfonamidesConceptsCell lung cancer cell linesLung cancer cell linesCancer cell linesCell cycle arrestNGI-1Tumor cellsCell linesEGFR