2000
Patterns of response to acute naloxone infusion in Tourette's syndrome
van Wattum P, Chappell P, Zelterman D, Scahill L, Leckman J. Patterns of response to acute naloxone infusion in Tourette's syndrome. Movement Disorders 2000, 15: 1252-1254. PMID: 11104215, DOI: 10.1002/1531-8257(200011)15:6<1252::aid-mds1030>3.0.co;2-i.Peer-Reviewed Original ResearchConceptsTourette syndromeTic behaviorsOpioid antagonist naloxoneDose-related effectsDose-response effectExpression of TSRandomized dosesAntagonist naloxoneNaloxone infusionOpioid receptorsLow doseHigh doseEarlier pilot studyPattern of responseSyndromeNaloxoneTS subjectsPilot studySignificant decreaseSignificant increaseDoseDifferent dosagesOpposite effectSubjectsVideotaped recordings
1996
Second solid tumors in patients with Hodgkin's disease cured after radiation or chemotherapy plus adjuvant low-dose radiation.
Salloum E, Doria R, Schubert W, Zelterman D, Holford T, Roberts K, Farber L, Kiehl R, Cardinale J, Cooper D. Second solid tumors in patients with Hodgkin's disease cured after radiation or chemotherapy plus adjuvant low-dose radiation. Journal Of Clinical Oncology 1996, 14: 2435-43. PMID: 8823321, DOI: 10.1200/jco.1996.14.9.2435.Peer-Reviewed Original ResearchConceptsOverall relative riskHodgkin's diseaseRT groupRelative riskSolid tumorsCMT groupRadiation therapyLung cancerBreast cancerEarly-stage Hodgkin's diseaseFull-dose radiation therapyInvolved-field radiationSecond solid tumorsConnecticut Tumor RegistryEarly-stage diseaseLong-term survivorsDifferent therapeutic approachesCases of lungLow-dose radiationSignificant increaseActuarial incidenceMedian followSalvage chemotherapyAdvanced diseaseDurable remissions
1991
Early Biochemical Events in Pneumococcal Otitis Media: Arachidonic Acid Metabolites in Middle Ear Fluid
Nonomura N, Giebink G, Harada T, Zelterman D, Juhn S. Early Biochemical Events in Pneumococcal Otitis Media: Arachidonic Acid Metabolites in Middle Ear Fluid. Annals Of Otology Rhinology & Laryngology 1991, 100: 385-388. PMID: 1850967, DOI: 10.1177/000348949110000507.Peer-Reviewed Original ResearchConceptsMiddle ear fluidArachidonic acid metabolitesEar fluidLeukotriene B4Acid metabolitesPneumococcal otitis mediaSubsequent inflammatory responseInflammatory cell chemotaxisStreptococcus pneumoniae organismsMiddle ear inoculationInflammatory cellsOtitis mediaF1 alphaInflammatory responseProstaglandin E2Pneumoniae organismsArachidonate metabolitesArachidonic acidCell chemotaxisEar inoculationEarly biochemical eventsSignificant increaseInitial stimulusHoursMetabolites