2000
Granulocyte-Macrophage Colony-Stimulating Factor Priming plus Papillomavirus E6 DNA Vaccination: Effects on Papilloma Formation and Regression in the Cottontail Rabbit Papillomavirus-Rabbit Model
Leachman S, Tigelaar R, Shlyankevich M, Slade M, Irwin M, Chang E, Wu T, Xiao W, Pazhani S, Zelterman D, Brandsma J. Granulocyte-Macrophage Colony-Stimulating Factor Priming plus Papillomavirus E6 DNA Vaccination: Effects on Papilloma Formation and Regression in the Cottontail Rabbit Papillomavirus-Rabbit Model. Journal Of Virology 2000, 74: 8700-8708. PMID: 10954571, PMCID: PMC116381, DOI: 10.1128/jvi.74.18.8700-8708.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiopsyCottontail rabbit papillomavirusDisease Models, AnimalDisease-Free SurvivalDNA, ViralGene Transfer TechniquesGenetic VectorsGranulocyte-Macrophage Colony-Stimulating FactorImmunohistochemistryIn Situ HybridizationPapillomaPapillomavirus InfectionsRabbitsTumor Virus InfectionsVaccines, DNAViral VaccinesConceptsGM-CSF primingGM-CSF treatmentDNA vaccinationDNA inoculationPapilloma formationGM-CSFProfessional antigen-presenting cellsMajor histocompatibility complex classDisease-free survivalVaccination-challenge experimentsAntigen-presenting cellsII-positive cellsGranulocyte-macrophage colony-stimulating factorHistocompatibility complex classColony-stimulating factorGranulocyte-macrophage colonyPapilloma volumeVaccination regimenClinical outcomesCutaneous sitesDNA vaccineViral challengePapilloma growthControl rabbitsCombination treatment
1999
Downregulation of p27KIP1 and Ki67/Mib1 Labeling Index Support the Classification of Thyroid Carcinoma Into Prognostically Relevant Categories
Tallini G, Garcia-Rostan G, Herrero A, Zelterman D, Viale G, Bosari S, Carcangiu M. Downregulation of p27KIP1 and Ki67/Mib1 Labeling Index Support the Classification of Thyroid Carcinoma Into Prognostically Relevant Categories. The American Journal Of Surgical Pathology 1999, 23: 678-685. PMID: 10366150, DOI: 10.1097/00000478-199906000-00007.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, FollicularAdultAgedCarcinoma, PapillaryCell Cycle ProteinsCyclin-Dependent Kinase Inhibitor p27Cyclin-Dependent KinasesDisease-Free SurvivalDown-RegulationFemaleHumansImmunoenzyme TechniquesKi-67 AntigenMaleMicrotubule-Associated ProteinsMiddle AgedPrognosisThyroid NeoplasmsTumor Suppressor ProteinsConceptsKi67/MIB1 labeling indexLow p27Kip1 expressionMIB1 labeling indexThyroid carcinomaFollicular carcinomaP27Kip1 expressionPathologic featuresPrognostic groupsTumor differentiationLabeling indexFavorable pathologic featuresKi67/MIB1Unfavorable pathologic featuresAdverse prognostic factorLarger tumor sizeFollicular cell originDownregulation of p27Kip1Valuable prognostic indicatorCellular proliferationCellular proliferation patternsCyclin-dependent kinase inhibitor p27Kip1High proliferative rateLow p27Kip1Prognostic factorsTumor size