Construction and Analysis of Multiparameter Prognostic Models for Melanoma Outcome
Rothberg BE, Rimm DL. Construction and Analysis of Multiparameter Prognostic Models for Melanoma Outcome. Methods In Molecular Biology 2013, 1102: 227-258. PMID: 24258982, PMCID: PMC3912557, DOI: 10.1007/978-1-62703-727-3_13.Peer-Reviewed Original ResearchConceptsAdjuvant regimensNegative sentinel lymph node biopsyAdverse risk-benefit ratioPrognostic modelStage II melanoma patientsSentinel lymph node biopsyConventional clinicopathologic criteriaLymph node biopsyStage II melanomaMelanoma-specific survivalWide local excisionRisk-benefit ratioKi-67 assaysTumor molecular profilesComposite prognostic indicesMost patientsNode biopsyLocal excisionMelanoma patientsPrognostic indexRisk stratificationClinicopathologic criteriaMelanoma outcomesPrognostic biomarkerIndependent cohortMarginal and Joint Distributions of S100, HMB-45, and Melan-A Across a Large Series of Cutaneous Melanomas
Viray H, Bradley WR, Schalper KA, Rimm DL, Rothberg BE. Marginal and Joint Distributions of S100, HMB-45, and Melan-A Across a Large Series of Cutaneous Melanomas. Archives Of Pathology & Laboratory Medicine 2013, 137: 1063-73. PMID: 23899062, PMCID: PMC3963468, DOI: 10.5858/arpa.2012-0284-oa.Peer-Reviewed Original ResearchConceptsHMB-45Primary tumorCutaneous melanomaLarge seriesMelanoma-specific survivalMelanoma primary tumorsGroup of antigensLarge tissue microarrayClinicopathologic covariatesClinicopathologic criteriaPrognostic relevanceHistopathologic profileClinicopathologic correlatesAntigen expressionClinicopathologic parametersMelanoma markersTissue microarrayPositive expressionSurvival analysisMelanomaMelanS100Melanoma cellsBivariate associationsSignificant differences