2017
Worldwide Frequency of Commonly Detected EGFR Mutations
Graham RP, Treece AL, Lindeman NI, Vasalos P, Shan M, Jennings LJ, Rimm DL. Worldwide Frequency of Commonly Detected EGFR Mutations. Archives Of Pathology & Laboratory Medicine 2017, 142: 163-167. PMID: 29106293, DOI: 10.5858/arpa.2016-0579-cp.Peer-Reviewed Original ResearchConceptsEGFR mutationsResistance mutationsEpidermal growth factor receptor (EGFR) mutationsProficiency testing programEGFR inhibitor therapyAmerican Pathologists Proficiency Testing ProgramCommon resistance mutationsT790M mutationClinical laboratoriesCalendar year 2013Mutation frequencyInhibitor therapyCommon mutation sitesLung cancerPulmonary adenocarcinomaL858R mutationReceptor mutationsFrequency of mutationsActivating mutationsEGFR inhibitorsM mutationAsian femalesExon 18Exon 20Ethnic differences
2016
EGFR-GRB2 Protein Colocalization Is a Prognostic Factor Unrelated to Overall EGFR Expression or EGFR Mutation in Lung Adenocarcinoma
Toki MI, Carvajal-Hausdorf DE, Altan M, McLaughlin J, Henick B, Schalper KA, Syrigos KN, Rimm DL. EGFR-GRB2 Protein Colocalization Is a Prognostic Factor Unrelated to Overall EGFR Expression or EGFR Mutation in Lung Adenocarcinoma. Journal Of Thoracic Oncology 2016, 11: 1901-1911. PMID: 27449805, PMCID: PMC5075503, DOI: 10.1016/j.jtho.2016.06.025.Peer-Reviewed Original ResearchConceptsEGFR pathway activationSeries of patientsLung adenocarcinomaMutation statusEGFR expressionPathway activationProximity ligation assayKRAS wild-type tumorsEGFR-mutant patientsKRAS-mutant casesCohort of patientsWild-type tumorsInteraction of EGFREGFR expression levelsEGFR protein expressionMAPK/ERK pathwayGrowth factor receptorActive EGFRPrognostic factorsDifferent mutation statusPatient groupPrognostic valueLonger survivalEGFR mutationsPrognostic marker
2010
Frequency of L858R and D746-750 EGFR mutations in 411 Caucasian patients with non-small cell lung cancer measured by mutation-specific antibodies.
Dimou A, Syrigos K, Agarwal S, Lozovatsky L, Zolota V, Anagnostou V, Rimm D. Frequency of L858R and D746-750 EGFR mutations in 411 Caucasian patients with non-small cell lung cancer measured by mutation-specific antibodies. Journal Of Clinical Oncology 2010, 28: 1587-1587. DOI: 10.1200/jco.2010.28.15_suppl.1587.Peer-Reviewed Original Research