2020
Immunological Differences Between Immune-Rich Estrogen Receptor–Positive and Immune-Rich Triple-Negative Breast Cancers
O’Meara T, Marczyk M, Qing T, Yaghoobi V, Blenman K, Cole K, Pelekanou V, Rimm DL, Pusztai L. Immunological Differences Between Immune-Rich Estrogen Receptor–Positive and Immune-Rich Triple-Negative Breast Cancers. JCO Precision Oncology 2020, 4: po.19.00350. PMID: 32923897, PMCID: PMC7446500, DOI: 10.1200/po.19.00350.Peer-Reviewed Original ResearchER-positive breast cancerTriple-negative BCM2-like macrophagesTumor-infiltrating lymphocytesBreast cancerImmune-related genesEstrogen receptor-positive breast cancerImmuno-oncology therapeutic targetsRegulatory T cell markersReceptor-positive breast cancerTriple-negative breast cancerImmune activation markersT-cell markersImmune cell markersM1-like macrophagesDifferent immunotherapy strategiesBreast Cancer International ConsortiumNegative breast cancerImmuno-oncology trialsTGF-β pathwayAntitumor immunityCancer Genome AtlasImmunotherapy strategiesActivation markersImmune microenvironmentAssociation between low estrogen receptor positive breast cancer and staining performance
Caruana D, Wei W, Martinez-Morilla S, Rimm DL, Reisenbichler ES. Association between low estrogen receptor positive breast cancer and staining performance. Npj Breast Cancer 2020, 6: 5. PMID: 32047851, PMCID: PMC7002746, DOI: 10.1038/s41523-020-0146-2.Peer-Reviewed Original ResearchER expressionER- tumorsBreast carcinomaTissue microarrayNormal epitheliumEstrogen receptor-positive breast cancerER casesReceptor-positive breast cancerControl patient populationER-positive tumorsEstrogen receptor expressionPositive breast cancerMean optical densityBackground epitheliumPositive tumorsControl cohortPatient populationControl tumorsReceptor expressionBenign epitheliumBreast cancerRare caseNormal ductsER stainingTumors
2018
Nuclear shape and orientation features from H&E images predict survival in early-stage estrogen receptor-positive breast cancers
Lu C, Romo-Bucheli D, Wang X, Janowczyk A, Ganesan S, Gilmore H, Rimm D, Madabhushi A. Nuclear shape and orientation features from H&E images predict survival in early-stage estrogen receptor-positive breast cancers. Laboratory Investigation 2018, 98: 1438-1448. PMID: 29959421, PMCID: PMC6214731, DOI: 10.1038/s41374-018-0095-7.Peer-Reviewed Original ResearchConceptsEarly-stage estrogen receptor-positive breast cancerEstrogen receptor-positive breast cancerReceptor-positive breast cancerBreast cancerRank sum testHazard ratioHistomorphometric featuresShort-term overall survivalLymph node negativeTissue microarray cohortPoor survival outcomesUnivariate survival analysisWilcoxon rank sum testAdjuvant chemotherapyMicroarray cohortOverall survivalNode negativeT stageHistology gradePatient survivalSurvival outcomesPathological parametersNuclear gradeOutcome groupPoor survival