2003
Detection of chromosomal instability in paired breast surgery and ductal lavage specimens by interphase fluorescence in situ hybridization.
King BL, Tsai SC, Gryga ME, D'Aquila TG, Seelig SA, Morrison LE, Jacobson KK, Legator MS, Ward DC, Rimm DL, Phillips RF. Detection of chromosomal instability in paired breast surgery and ductal lavage specimens by interphase fluorescence in situ hybridization. Clinical Cancer Research 2003, 9: 1509-16. PMID: 12684427.Peer-Reviewed Original ResearchConceptsDuctal lavageMalignant casesBenign casesBreast lesionsBreast cellsInvasive breast cancerInterphase fluorescenceBreast cancer progressionAbnormal cytologyLavage cellsSitu hybridizationBreast surgeryBreast cancerEarly neoplasiaConventional cytologyLavageGenetic abnormalitiesCancer progressionNew modalityNumeric changesSitu hybridization analysisSurgeryLesionsCytologyAbnormalities
2001
Use of magnetic enrichment for detection of carcinoma cells in fluid specimens
Kielhorn E, Schofield K, Rimm DL. Use of magnetic enrichment for detection of carcinoma cells in fluid specimens. Cancer 2001, 94: 205-211. PMID: 11815978, DOI: 10.1002/cncr.10193.Peer-Reviewed Original ResearchConceptsFluid specimensEpithelial cellsCarcinoma cellsCell enrichmentDetection of malignancyDetermination of malignancyRare epithelial cellsE-cadherin stainingPleural effusionAccurate stagingMetastatic carcinomaCytologic evaluationCytologic diagnosisMedical conditionsAtypical casesMalignant casesMalignant cellsInsufficient cellsNegative casesImmunomagnetic enrichmentAscites fluidMalignancyImmunomagnetic selectionCommon event