2021
STING enhances cell death through regulation of reactive oxygen species and DNA damage
Hayman TJ, Baro M, MacNeil T, Phoomak C, Aung TN, Cui W, Leach K, Iyer R, Challa S, Sandoval-Schaefer T, Burtness BA, Rimm DL, Contessa JN. STING enhances cell death through regulation of reactive oxygen species and DNA damage. Nature Communications 2021, 12: 2327. PMID: 33875663, PMCID: PMC8055995, DOI: 10.1038/s41467-021-22572-8.Peer-Reviewed Original Research
2012
PKCε Promotes Oncogenic Functions of ATF2 in the Nucleus while Blocking Its Apoptotic Function at Mitochondria
Lau E, Kluger H, Varsano T, Lee K, Scheffler I, Rimm DL, Ideker T, Ronai ZA. PKCε Promotes Oncogenic Functions of ATF2 in the Nucleus while Blocking Its Apoptotic Function at Mitochondria. Cell 2012, 148: 543-555. PMID: 22304920, PMCID: PMC3615433, DOI: 10.1016/j.cell.2012.01.016.Peer-Reviewed Original ResearchConceptsTumor suppressor functionGenotoxic stressNuclear exportSuppressor functionTranscription factor ATF2Tumor suppressor activityApoptotic functionSubcellular localizationMelanoma tumor samplesNuclear localizationMitochondrial permeabilityOncogenic functionOncogenic activityATF2MitochondriaPKCε levelsSuppressor activityMembrane permeabilityMelanoma cellsPKCεApoptosisTumor samplesLocalization