2023
A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways
Ye Y, Noche R, Szejko N, Both C, Acosta J, Leasure A, Brown S, Sheth K, Gill T, Zhao H, Falcone G. A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways. GeroScience 2023, 45: 2511-2523. PMID: 36928559, PMCID: PMC10651618, DOI: 10.1007/s11357-023-00771-z.Peer-Reviewed Original ResearchConceptsFried frailty scoreBiology of frailtyEuropean descent participantsOccurrence of frailtyGenome-wide association studiesMendelian randomization analysisFrailty scoreChronic painJoint disordersPolygenic risk scoresRespiratory diseaseInflammation pathwaysRisk scoreClinical phenotypeBrain tissueCausal associationFrailtyAge-related pathwaysRandomization analysisGenetic factorsAssociation studiesUK BiobankRetirement StudyPerson's vulnerabilitySignificant genetic correlations
2019
Harmonizing Genetic Ancestry and Self-identified Race/Ethnicity in Genome-wide Association Studies
Fang H, Hui Q, Lynch J, Honerlaw J, Assimes T, Huang J, Vujkovic M, Damrauer S, Pyarajan S, Gaziano J, DuVall S, O’Donnell C, Cho K, Chang K, Wilson P, Tsao P, Sun Y, Tang H, Gaziano J, Ramoni R, Breeling J, Chang K, Huang G, Muralidhar S, O’Donnell C, Tsao P, Muralidhar S, Moser J, Whitbourne S, Brewer J, Concato J, Warren S, Argyres D, Stephens B, Brophy M, Humphries D, Do N, Shayan S, Nguyen X, Pyarajan S, Cho K, Hauser E, Sun Y, Zhao H, Wilson P, McArdle R, Dellitalia L, Harley J, Whittle J, Beckham J, Wells J, Gutierrez S, Gibson G, Kaminsky L, Villareal G, Kinlay S, Xu J, Hamner M, Haddock K, Bhushan S, Iruvanti P, Godschalk M, Ballas Z, Buford M, Mastorides S, Klein J, Ratcliffe N, Florez H, Swann A, Murdoch M, Sriram P, Yeh S, Washburn R, Jhala D, Aguayo S, Cohen D, Sharma S, Callaghan J, Oursler K, Whooley M, Ahuja S, Gutierrez A, Schifman R, Greco J, Rauchman M, Servatius R, Oehlert M, Wallbom A, Fernando R, Morgan T, Stapley T, Sherman S, Anderson G, Sonel E, Boyko E, Meyer L, Gupta S, Fayad J, Hung A, Lichy J, Hurley R, Robey B, Striker R. Harmonizing Genetic Ancestry and Self-identified Race/Ethnicity in Genome-wide Association Studies. American Journal Of Human Genetics 2019, 105: 763-772. PMID: 31564439, PMCID: PMC6817526, DOI: 10.1016/j.ajhg.2019.08.012.Peer-Reviewed Original Research
1997
Strategies to Identify Genes for Complex Diseases
Zhang H, Zhao H, Merikangas K. Strategies to Identify Genes for Complex Diseases. Annals Of Medicine 1997, 29: 493-498. PMID: 9562515, DOI: 10.3109/07853899709007473.Peer-Reviewed Original ResearchConceptsComplex diseasesNumerous human diseasesDisease-susceptible genesComplex human disordersHuman genomeGenetic basisHuman disordersHuman diseasesMolecular biologyGenesGenetic epidemiological studiesGenetic factorsComplex patternsDisease pathophysiologyGenomeBiologyTraitsInheritanceMultiple sclerosisBreast cancerEpidemiological studies