2020
Statistical Methods in Genome-Wide Association Studies
Sun N, Zhao H. Statistical Methods in Genome-Wide Association Studies. Annual Review Of Biomedical Data Science 2020, 3: 1-24. DOI: 10.1146/annurev-biodatasci-030320-041026.Peer-Reviewed Original ResearchGenome-wide association studiesAssociation studiesTraits of interestGenetic architectureIdentification of variantsGWAS dataStatistical methodologyStatistical challengesGenetic risk prediction modelsGenetic markersStatistical methodsHuman diseasesPhenotype informationGenetic variantsTraitsGenotype informationScientific goalsRecent progressGenesVariantsTens of thousandsHundreds of thousandsPrediction modelPathwayThousands
2015
Gene-based and pathway-based genome-wide association study of alcohol dependence
Lingjun Z, ZHANG CK, SAYWARD FG, CHEUNG KH, Kesheng W, KRYSTAL JH, Hongyu Z, Xingguang L. Gene-based and pathway-based genome-wide association study of alcohol dependence. General Psychiatry 2015, 27: 111-118. PMID: 26120261, PMCID: PMC4466852, DOI: 10.11919/j.issn.1002-0829.215031.Peer-Reviewed Original ResearchGenome-wide association studiesRisk genesAssociation studiesBiological signaling processesPXN geneGene pathwaysSignaling processesGlycan degradationInteraction pathwayGenetic markersTransporter pathwaysGenesDiscovery samplePathwayReplication sampleAfrican American casesRisk pathwaysMultiple testingBonferroni correctionNew evidence
2001
Test of Association for Quantitative Traits in General Pedigrees: The Quantitative Pedigree Disequilibrium Test
Zhang S, Zhang K, Li J, Sun F, Zhao H. Test of Association for Quantitative Traits in General Pedigrees: The Quantitative Pedigree Disequilibrium Test. Genetic Epidemiology 2001, 21: s370-s375. PMID: 11793701, DOI: 10.1002/gepi.2001.21.s1.s370.Peer-Reviewed Original ResearchConceptsQuantitative pedigree disequilibrium testPedigree disequilibrium testQuantitative traitsTraits of interestGenetic Analysis Workshop 12Disequilibrium testGeneral pedigreesSequence dataCandidate genesGenetic markersGenetic linkageQualitative traitsLinkage disequilibriumTraitsLarge pedigreePresence of linkagePedigreeStatistical methodsFamilyNuclear familiesTests of associationGenesUnrelated nuclear familiesLinkageDisequilibrium