2024
A mediation analysis framework based on variance component to remove genetic confounding effect
Dong Z, Zhao H, DeWan A. A mediation analysis framework based on variance component to remove genetic confounding effect. Journal Of Human Genetics 2024, 69: 301-309. PMID: 38528049, DOI: 10.1038/s10038-024-01232-x.Peer-Reviewed Original ResearchMediation analysis frameworkSingle nucleotide polymorphismsMediation analysisPleiotropic single nucleotide polymorphismsUK Biobank dataConfounding effectsTrait pairsBiobank dataIndividual-levelEpidemiological studiesCausal effectsGenetic signalsEstimated effectsLinear regressionNucleotide polymorphismsStandard errorData analysisGenetic correlationsPhenotypeIndirect effectsPleiotropyVariance componentsOutcomesRegression
2015
eQTL mapping
Chen M, Yang C, Li C, Zhao H. eQTL mapping. 2015, 208-228. DOI: 10.1017/cbo9781107337459.016.Peer-Reviewed Original ResearchGenome-wide association studiesAssociation studiesPopulation genomic studiesQuantitative trait lociComplex diseasesEQTL mappingTrait lociGenomic studiesSingle nucleotide polymorphismsGenetic basisNumber variantsNucleotide polymorphismsPharmaceutical potentialUnique resourceGenomicsLociBroad impactHaplotypesPolymorphismIntroduction to statistical methods in genome-wide association studies
Yang C, Li C, Chung D, Chen M, Gelernter J, Zhao H. Introduction to statistical methods in genome-wide association studies. 2015, 26-52. DOI: 10.1017/cbo9781107337459.005.Peer-Reviewed Original ResearchGenome-wide association studiesAssociation studiesPopulation genomic studiesQuantitative trait lociComplex diseasesTrait lociGenomic studiesSingle nucleotide polymorphismsGenetic basisNumber variantsNucleotide polymorphismsPharmaceutical potentialUnique resourceGenomicsLociBroad impactHaplotypesStatistical methodsPolymorphismVariantsPharmacogenomics