2000
Family-based association studies
Zhao H. Family-based association studies. Statistical Methods In Medical Research 2000, 9: 563-587. PMID: 11308071, DOI: 10.1177/096228020000900604.Peer-Reviewed Original ResearchConceptsFamily-based association designComplex disease genesDisease genesBias due to population stratificationDetect gene-environment interactionsAssociation studiesLinkage studiesIncomplete parental genotypesPresence of population substructureAssociation designFamily-based association studyStudy quantitative traitsTraditional linkage studiesMendelian disease genesBiallelic genetic markerCase-control association studyGene-environment interactionsHuman Genome ProjectCase-control studyMultiallelic markersPopulation substructurePopulation stratificationPedigree structureGenome ProjectPositional cloning
1999
On a Randomization Procedure in Linkage Analysis
Zhao H, Merikangas K, Kidd K. On a Randomization Procedure in Linkage Analysis. American Journal Of Human Genetics 1999, 65: 1449-1456. PMID: 10521312, PMCID: PMC1288298, DOI: 10.1086/302607.Peer-Reviewed Original ResearchConceptsEfficient simulation procedureObserved test statisticSimulation-based methodTheoretical resultsTest statisticNovel simulation methodSimulation methodReal dataSimulation procedureUninformative markersTheoretical workStatistical testsPedigree structureGenomewide significance levelRandomization procedureDiabetes dataStatisticsA more powerful method to evaluate p‐values in GENEHUNTER
Zhao H, Sheffield L, Pakstis A, Knauert M, Kidd K. A more powerful method to evaluate p‐values in GENEHUNTER. Genetic Epidemiology 1999, 17: s415-s420. PMID: 10597472, DOI: 10.1002/gepi.1370170770.Peer-Reviewed Original Research