Featured Publications
Statistical Methods for Analyzing Tree-Structured Microbiome Data
Wang T, Zhao H. Statistical Methods for Analyzing Tree-Structured Microbiome Data. Frontiers In Probability And The Statistical Sciences 2021, 193-220. DOI: 10.1007/978-3-030-73351-3_8.Peer-Reviewed Original ResearchStatistical methodsOnly relative informationMicrobiome data analysisMicrobiome dataEmpirical Bayes estimationCompositional predictorsBayes estimationComputational challengesRelative informationDimension reductionAbundance matrixTaxa countsMultinomial modelMicrobiome datasetsPhylogenetic informationMicrobial taxaPhylogenetic treeSequencing technologiesOriginal ecosystemMicrobial compositionOrders of magnitudeMatrixExperimental methodsLibrary sizeZeros
2022
phyloMDA: an R package for phylogeny-aware microbiome data analysis
Liu T, Zhou C, Wang H, Zhao H, Wang T. phyloMDA: an R package for phylogeny-aware microbiome data analysis. BMC Bioinformatics 2022, 23: 213. PMID: 35668363, PMCID: PMC9169257, DOI: 10.1186/s12859-022-04744-5.Peer-Reviewed Original ResearchConceptsHost-associated microbial communitiesShared evolutionary historyMicrobiome data analysisEvolutionary historyPhylogenetic informationPhylogenetic treeMicrobial communitiesR packageSequencing technologiesAbundance dataMicrobial compositionRelative abundanceMicrobiome dataSample sitesUser-friendly toolMultivariate abundance dataAbundanceUnique opportunityUnprecedented scaleDifferent patternsTrees