2023
Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo
May D, Yun S, Gonzalez D, Park S, Chen Y, Lathrop E, Cai B, Xin T, Zhao H, Wang S, Gonzalez L, Cockburn K, Greco V. Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo. ELife 2023, 12: e83444. PMID: 36880644, PMCID: PMC10027315, DOI: 10.7554/elife.83444.Peer-Reviewed Original ResearchConceptsStem cell differentiationCell differentiationStem cell compartmentCompaction changesChromatin compaction statesDynamic transcriptional statesCell compartmentChromatin architectureCell cycle statusChromatin rearrangementNascent RNATranscriptional burstingTranscriptional statesLive imagingTissue contextGene expressionDifferentiating cellsGlobal remodelingIndividual cellsCycle statusStem cellsDifferentiation statusDifferentiationCellsMorphological changes
2022
Pan-Cancer Single-Cell Analysis Reveals the Core Factors and Pathway in Specific Cancer Stem Cells of Upper Gastrointestinal Cancer
Li L, Zhang Y, Ren Y, Cheng Z, Zhang Y, Wang X, Zhao H, Lu H. Pan-Cancer Single-Cell Analysis Reveals the Core Factors and Pathway in Specific Cancer Stem Cells of Upper Gastrointestinal Cancer. Frontiers In Bioengineering And Biotechnology 2022, 10: 849798. PMID: 35646860, PMCID: PMC9136039, DOI: 10.3389/fbioe.2022.849798.Peer-Reviewed Original ResearchUpper gastrointestinal cancerCancer stem cellsPoor eating habitsTumor stem cellsChronic inflammationGastrointestinal cancerEating habitsStem cellsGastrointestinal cancer stem cellsPersistent chronic inflammationGastrointestinal cancer diagnosisCore signal pathwaysWnt pathway genesMucosa damagePoor outcomeAggressive carcinomasInflammatory genesSpecific cancer stem cellsCancer diagnosisCancerSignal pathwayInflammationWnt pathwayCell typesCells