2019
Prediction analysis for microbiome sequencing data
Wang T, Yang C, Zhao H. Prediction analysis for microbiome sequencing data. Biometrics 2019, 75: 875-884. PMID: 30994187, DOI: 10.1111/biom.13061.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBacteriaHumansLikelihood FunctionsMicrobiotaMonte Carlo MethodRegression AnalysisSequence AnalysisConceptsMonte Carlo expectation-maximization algorithmInverse regression modelReal data exampleTypes of covariatesNew statistical frameworkMaximum likelihood estimationExpectation-maximization algorithmDimension reduction structureInverse regressionStatistical frameworkData examplesStatistical challengesLikelihood estimationMicrobiome sequencing dataHuman microbiome studiesHuman microbiome compositionDifferent library sizesZerosPredictive analysisModelEstimationAlgorithmSimulationsRegression modelsFramework
2017
A Dirichlet-Tree Multinomial Regression Model for Associating Dietary Nutrients with Gut Microorganisms
Wang T, Zhao H. A Dirichlet-Tree Multinomial Regression Model for Associating Dietary Nutrients with Gut Microorganisms. Biometrics 2017, 73: 792-801. PMID: 28112797, PMCID: PMC5587402, DOI: 10.1111/biom.12654.Peer-Reviewed Original ResearchMeSH KeywordsDietGastrointestinal MicrobiomeHumansLikelihood FunctionsPhylogenyRegression AnalysisStatistical Distributions
2001
Multipoint Genetic Mapping with Trisomy Data
Li J, Sherman S, Lamb N, Zhao H. Multipoint Genetic Mapping with Trisomy Data. American Journal Of Human Genetics 2001, 69: 1255-1265. PMID: 11704925, PMCID: PMC1235537, DOI: 10.1086/324578.Peer-Reviewed Original ResearchConceptsExpectation-maximization algorithmMultipoint genetic mappingAmount of computationProbability distributionTrisomy dataStatistical methodsFirst approachMarkov modelSecond approachProbabilityCrossover processComputationLarge numberSetModelApproachGeneral relationshipDistributionAlgorithmNumber of markersComparisons of Two Methods for Haplotype Reconstruction and Haplotype Frequency Estimation from Population Data
Zhang S, Pakstis A, Kidd K, Zhao H. Comparisons of Two Methods for Haplotype Reconstruction and Haplotype Frequency Estimation from Population Data. American Journal Of Human Genetics 2001, 69: 906-912. PMID: 11536083, PMCID: PMC1226079, DOI: 10.1086/323622.Peer-Reviewed Original ResearchOn Relationship Inference Using Gamete Identity by Descent Data
Zhao H, Liang F. On Relationship Inference Using Gamete Identity by Descent Data. Journal Of Computational Biology 2001, 8: 191-200. PMID: 11454305, DOI: 10.1089/106652701300312940.Peer-Reviewed Original Research
2000
Multipoint Genetic Mapping with Uniparental Disomy Data
Zhao H, Li J, Robinson W. Multipoint Genetic Mapping with Uniparental Disomy Data. American Journal Of Human Genetics 2000, 67: 851-861. PMID: 10958760, PMCID: PMC1287890, DOI: 10.1086/303072.Peer-Reviewed Original ResearchHaplotypes and Linkage Disequilibrium at the Phenylalanine Hydroxylase Locus, PAH, in a Global Representation of Populations
Kidd J, Pakstis A, Zhao H, Lu R, Okonofua F, Odunsi A, Grigorenko E, Tamir B, Friedlaender J, Schulz L, Parnas J, Kidd K. Haplotypes and Linkage Disequilibrium at the Phenylalanine Hydroxylase Locus, PAH, in a Global Representation of Populations. American Journal Of Human Genetics 2000, 66: 1882-1899. PMID: 10788337, PMCID: PMC1378054, DOI: 10.1086/302952.Peer-Reviewed Original Research