Featured Publications
SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits
Zhang Y, Lu Q, Ye Y, Huang K, Liu W, Wu Y, Zhong X, Li B, Yu Z, Travers BG, Werling DM, Li JJ, Zhao H. SUPERGNOVA: local genetic correlation analysis reveals heterogeneous etiologic sharing of complex traits. Genome Biology 2021, 22: 262. PMID: 34493297, PMCID: PMC8422619, DOI: 10.1186/s13059-021-02478-w.Peer-Reviewed Original ResearchMeSH KeywordsAutism Spectrum DisorderCognitionComputer SimulationGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMultifactorial InheritanceQuantitative Trait, HeritableRisk FactorsSoftwareConceptsLocal genetic correlationsComplex traitsGenetic correlationsGenomic regionsLocal genetic correlation analysisGenome-wide association studiesLocal genomic regionsSpecific genomic regionsGenetic correlation analysisDistinct genetic signaturesGenetic similarityGenetic signaturesAssociation studiesTraitsSample overlapStatistical frameworkSummary statisticsDisequilibriumRegionAccurate estimationSimilarity
2001
Test of Association for Quantitative Traits in General Pedigrees: The Quantitative Pedigree Disequilibrium Test
Zhang S, Zhang K, Li J, Sun F, Zhao H. Test of Association for Quantitative Traits in General Pedigrees: The Quantitative Pedigree Disequilibrium Test. Genetic Epidemiology 2001, 21: s370-s375. PMID: 11793701, DOI: 10.1002/gepi.2001.21.s1.s370.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingGenetic MarkersGenetic Predisposition to DiseaseGenetic VariationHumansLinkage DisequilibriumLod ScoreModels, GeneticPedigreePolymorphism, GeneticQuantitative Trait, HeritableConceptsQuantitative pedigree disequilibrium testPedigree disequilibrium testQuantitative traitsTraits of interestGenetic Analysis Workshop 12Disequilibrium testGeneral pedigreesSequence dataCandidate genesGenetic markersGenetic linkageQualitative traitsLinkage disequilibriumTraitsLarge pedigreePresence of linkagePedigreeStatistical methodsFamilyNuclear familiesTests of associationGenesUnrelated nuclear familiesLinkageDisequilibriumThe Power of Transmission Disequilibrium Tests for Quantitative Traits
Li J, Wang D, Dong J, Jiang R, Zhang K, Zhang S, Zhao H, Sun F. The Power of Transmission Disequilibrium Tests for Quantitative Traits. Genetic Epidemiology 2001, 21: s632-s637. PMID: 11793752, DOI: 10.1002/gepi.2001.21.s1.s632.Peer-Reviewed Original ResearchAdultChildFemaleGenetic MarkersGenotypeHaplotypesHumansLinkage DisequilibriumLod ScoreMaleModels, GeneticQuantitative Trait, Heritable
2000
Transmission/disequilibrium tests for quantitative traits.
Sun F, Flanders W, Yang Q, Zhao H. Transmission/disequilibrium tests for quantitative traits. Annals Of Human Genetics 2000, 64: 555-65. PMID: 11281218, DOI: 10.1017/s000348000000840x.Peer-Reviewed Original ResearchComputer SimulationFemaleGenetic LinkageHumansMaleModels, GeneticPedigreeQuantitative Trait, Heritable