2018
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Chou YL, Degenhardt F, Docherty AR, Edwards AC, Fontanillas P, Foo JC, Fox L, Frank J, Giegling I, Gordon S, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Herms S, Hodgkinson C, Hoffmann P, Jan Hottenga J, Kennedy MA, Alanne-Kinnunen M, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Pearson JF, Peterson RE, Ripatti S, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, Boardman J, Chen D, Choi D, Copeland W, Culverhouse R, Dahmen N, Degenhardt L, Domingue B, Elson S, Frye M, Gäbel W, Hayward C, Ising M, Keyes M, Kiefer F, Kramer J, Kuperman S, Lucae S, Lynskey M, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray A, Nurnberger J, Palotie A, Preuss U, Räikkönen K, Reynolds M, Ridinger M, Scherbaum N, Schuckit M, Soyka M, Treutlein J, Witt S, Wodarz N, Zill P, Adkins D, Boden J, Boomsma D, Bierut L, Brown S, Bucholz K, Cichon S, Costello E, de Wit H, Diazgranados N, Dick D, Eriksson J, Farrer L, Foroud T, Gillespie N, Goate A, Goldman D, Grucza R, Hancock D, Harris K, Heath A, Hesselbrock V, Hewitt J, Hopfer C, Horwood J, Iacono W, Johnson E, Kaprio J, Karpyak V, Kendler K, Kranzler H, Krauter K, Lichtenstein P, Lind P, McGue M, MacKillop J, Madden P, Maes H, Magnusson P, Martin N, Medland S, Montgomery G, Nelson E, Nöthen M, Palmer A, Pedersen N, Penninx B, Porjesz B, Rice J, Rietschel M, Riley B, Rose R, Rujescu D, Shen P, Silberg J, Stallings M, Tarter R, Vanyukov M, Vrieze S, Wall T, Whitfield J, Zhao H, Neale B, Gelernter J, Edenberg H, Agrawal A. Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nature Neuroscience 2018, 21: 1656-1669. PMID: 30482948, PMCID: PMC6430207, DOI: 10.1038/s41593-018-0275-1.Peer-Reviewed Original ResearchConceptsGenetic underpinningsGenome-wide association studiesGenome-wide dataLarge genome-wide association studiesGenome-wide significant effectComplex polygenic architectureSignificant genetic correlationsPolygenic architectureGenetic distinctionCommon genetic underpinningsAssociation studiesGenetic relationshipsGenetic correlationsGenetic ancestryFamily-based studyUse of cigarettesAttention deficit hyperactivity disorder
2001
Comparisons of Two Methods for Haplotype Reconstruction and Haplotype Frequency Estimation from Population Data
Zhang S, Pakstis A, Kidd K, Zhao H. Comparisons of Two Methods for Haplotype Reconstruction and Haplotype Frequency Estimation from Population Data. American Journal Of Human Genetics 2001, 69: 906-912. PMID: 11536083, PMCID: PMC1226079, DOI: 10.1086/323622.Peer-Reviewed Original Research
2000
Family-based association studies
Zhao H. Family-based association studies. Statistical Methods In Medical Research 2000, 9: 563-587. PMID: 11308071, DOI: 10.1177/096228020000900604.Peer-Reviewed Original ResearchConceptsFamily-based association designComplex disease genesDisease genesBias due to population stratificationDetect gene-environment interactionsAssociation studiesLinkage studiesIncomplete parental genotypesPresence of population substructureAssociation designFamily-based association studyStudy quantitative traitsTraditional linkage studiesMendelian disease genesBiallelic genetic markerCase-control association studyGene-environment interactionsHuman Genome ProjectCase-control studyMultiallelic markersPopulation substructurePopulation stratificationPedigree structureGenome ProjectPositional cloningMultipoint Genetic Mapping with Uniparental Disomy Data
Zhao H, Li J, Robinson W. Multipoint Genetic Mapping with Uniparental Disomy Data. American Journal Of Human Genetics 2000, 67: 851-861. PMID: 10958760, PMCID: PMC1287890, DOI: 10.1086/303072.Peer-Reviewed Original ResearchHaplotypes and Linkage Disequilibrium at the Phenylalanine Hydroxylase Locus, PAH, in a Global Representation of Populations
Kidd J, Pakstis A, Zhao H, Lu R, Okonofua F, Odunsi A, Grigorenko E, Tamir B, Friedlaender J, Schulz L, Parnas J, Kidd K. Haplotypes and Linkage Disequilibrium at the Phenylalanine Hydroxylase Locus, PAH, in a Global Representation of Populations. American Journal Of Human Genetics 2000, 66: 1882-1899. PMID: 10788337, PMCID: PMC1378054, DOI: 10.1086/302952.Peer-Reviewed Original Research
1999
The Interpretation of the Parameters in the Transmission/Disequilibrium Test
Zhao H. The Interpretation of the Parameters in the Transmission/Disequilibrium Test. American Journal Of Human Genetics 1999, 64: 326-328. PMID: 9915979, PMCID: PMC1377738, DOI: 10.1086/302208.Peer-Reviewed Original Research
1998
A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus
Kidd K, Morar B, Castiglione C, Zhao H, Pakstis A, Speed W, Bonne-Tamir B, Lu R, Goldman D, Lee C, Nam Y, Grandy D, Jenkins T, Kidd J. A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus. Human Genetics 1998, 103: 211-227. PMID: 9760208, DOI: 10.1007/s004390050809.Peer-Reviewed Original Research